Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.

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Autores principales:	Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/760f4386456742798a6a43da19805d86
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spelling	oai:doaj.org-article:760f4386456742798a6a43da19805d862021-12-02T14:40:12ZTumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression10.1038/ncomms119042041-1723https://doaj.org/article/760f4386456742798a6a43da19805d862016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11904https://doaj.org/toc/2041-1723HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.Ting-Fang ChouYa-Ting ChuangWan-Chen HsiehPei-Yun ChangHsin-Yu LiuShu-Ting MoTzu-Sheng HsuShi-Chuen MiawRuey-Hwa ChenAdi KimchiMing-Zong LaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting-Fang Chou Ya-Ting Chuang Wan-Chen Hsieh Pei-Yun Chang Hsin-Yu Liu Shu-Ting Mo Tzu-Sheng Hsu Shi-Chuen Miaw Ruey-Hwa Chen Adi Kimchi Ming-Zong Lai Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
description	HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.
format	article
author	Ting-Fang Chou Ya-Ting Chuang Wan-Chen Hsieh Pei-Yun Chang Hsin-Yu Liu Shu-Ting Mo Tzu-Sheng Hsu Shi-Chuen Miaw Ruey-Hwa Chen Adi Kimchi Ming-Zong Lai
author_facet	Ting-Fang Chou Ya-Ting Chuang Wan-Chen Hsieh Pei-Yun Chang Hsin-Yu Liu Shu-Ting Mo Tzu-Sheng Hsu Shi-Chuen Miaw Ruey-Hwa Chen Adi Kimchi Ming-Zong Lai
author_sort	Ting-Fang Chou
title	Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
title_short	Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
title_full	Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
title_fullStr	Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
title_full_unstemmed	Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
title_sort	tumour suppressor death-associated protein kinase targets cytoplasmic hif-1α for th17 suppression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/760f4386456742798a6a43da19805d86
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Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

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