Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.

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Detalles Bibliográficos
Autores principales: Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/760f4386456742798a6a43da19805d86
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https://doaj.org/article/760f4386456742798a6a43da19805d86

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