Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
|
| Subjects: | |
| Online Access: | https://doaj.org/article/760f4386456742798a6a43da19805d86 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|