The role of ferroptosis in lung cancer

Abstract Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually character...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sikai Wu, Chengchu Zhu, Daolin Tang, Q. Ping Dou, Jianfei Shen, Xin Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ferroptosis Lung cancer iron Lipid peroxidation ROS Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/76101d5c7cee43febf22360a696dc85a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76101d5c7cee43febf22360a696dc85a
record_format	dspace
spelling	oai:doaj.org-article:76101d5c7cee43febf22360a696dc85a2021-11-07T12:12:52ZThe role of ferroptosis in lung cancer10.1186/s40364-021-00338-02050-7771https://doaj.org/article/76101d5c7cee43febf22360a696dc85a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00338-0https://doaj.org/toc/2050-7771Abstract Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.Sikai WuChengchu ZhuDaolin TangQ. Ping DouJianfei ShenXin ChenBMCarticleFerroptosisLung cancerironLipid peroxidationROSTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ferroptosis Lung cancer iron Lipid peroxidation ROS Therapeutics. Pharmacology RM1-950
spellingShingle	Ferroptosis Lung cancer iron Lipid peroxidation ROS Therapeutics. Pharmacology RM1-950 Sikai Wu Chengchu Zhu Daolin Tang Q. Ping Dou Jianfei Shen Xin Chen The role of ferroptosis in lung cancer
description	Abstract Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
format	article
author	Sikai Wu Chengchu Zhu Daolin Tang Q. Ping Dou Jianfei Shen Xin Chen
author_facet	Sikai Wu Chengchu Zhu Daolin Tang Q. Ping Dou Jianfei Shen Xin Chen
author_sort	Sikai Wu
title	The role of ferroptosis in lung cancer
title_short	The role of ferroptosis in lung cancer
title_full	The role of ferroptosis in lung cancer
title_fullStr	The role of ferroptosis in lung cancer
title_full_unstemmed	The role of ferroptosis in lung cancer
title_sort	role of ferroptosis in lung cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/76101d5c7cee43febf22360a696dc85a
work_keys_str_mv	AT sikaiwu theroleofferroptosisinlungcancer AT chengchuzhu theroleofferroptosisinlungcancer AT daolintang theroleofferroptosisinlungcancer AT qpingdou theroleofferroptosisinlungcancer AT jianfeishen theroleofferroptosisinlungcancer AT xinchen theroleofferroptosisinlungcancer AT sikaiwu roleofferroptosisinlungcancer AT chengchuzhu roleofferroptosisinlungcancer AT daolintang roleofferroptosisinlungcancer AT qpingdou roleofferroptosisinlungcancer AT jianfeishen roleofferroptosisinlungcancer AT xinchen roleofferroptosisinlungcancer
_version_	1718443495667007488

The role of ferroptosis in lung cancer

Ejemplares similares