GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma

Abstract GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between...

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Autores principales:	Yilin Yu, Zhiping Wang, Qunhao Zheng, Jiancheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7612221b6cdc45ff92169819ce01f275
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spelling	oai:doaj.org-article:7612221b6cdc45ff92169819ce01f2752021-12-02T16:06:09ZGREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma10.1038/s41598-021-92695-x2045-2322https://doaj.org/article/7612221b6cdc45ff92169819ce01f2752021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92695-xhttps://doaj.org/toc/2045-2322Abstract GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, HPA, TIMER, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, GREB1L expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high GREB1L expression levels were correlated with a poor OS in LUAD. Additionally, GREB1L expression was independently associated with OS through a multivariate Cox analysis. GSEA analysis revealed enrichment in cell cycle, immune regulation, and methylation. Moreover, high GREB1L expression was associated with poor survival. We also found that the methylation and genetic alteration level was associated with prognosis in patients with LUAD. Finally, an analysis of immune infiltration showed that GREB1L is correlated with immune cell infiltration, PD-1, and PD-L1. In summary, these results indicate that GREB1L is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers.Yilin YuZhiping WangQunhao ZhengJiancheng LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yilin Yu Zhiping Wang Qunhao Zheng Jiancheng Li GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
description	Abstract GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, HPA, TIMER, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, GREB1L expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high GREB1L expression levels were correlated with a poor OS in LUAD. Additionally, GREB1L expression was independently associated with OS through a multivariate Cox analysis. GSEA analysis revealed enrichment in cell cycle, immune regulation, and methylation. Moreover, high GREB1L expression was associated with poor survival. We also found that the methylation and genetic alteration level was associated with prognosis in patients with LUAD. Finally, an analysis of immune infiltration showed that GREB1L is correlated with immune cell infiltration, PD-1, and PD-L1. In summary, these results indicate that GREB1L is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers.
format	article
author	Yilin Yu Zhiping Wang Qunhao Zheng Jiancheng Li
author_facet	Yilin Yu Zhiping Wang Qunhao Zheng Jiancheng Li
author_sort	Yilin Yu
title	GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_short	GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_full	GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_fullStr	GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_full_unstemmed	GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_sort	greb1l overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7612221b6cdc45ff92169819ce01f275
work_keys_str_mv	AT yilinyu greb1loverexpressioncorrelateswithprognosisandimmunecellinfiltrationinlungadenocarcinoma AT zhipingwang greb1loverexpressioncorrelateswithprognosisandimmunecellinfiltrationinlungadenocarcinoma AT qunhaozheng greb1loverexpressioncorrelateswithprognosisandimmunecellinfiltrationinlungadenocarcinoma AT jianchengli greb1loverexpressioncorrelateswithprognosisandimmunecellinfiltrationinlungadenocarcinoma
_version_	1718385095564328960

GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma

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