Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction

Rui Wang,1 Xiaodan Wen,2 Cheng Huang,1 Yingcong Liang,1 Yujing Mo,1 Ling Xue11Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 2Department of Geriatr...

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Autores principales:	Wang R, Wen X, Huang C, Liang Y, Mo Y, Xue L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	inflammation-based prognostic scores acute myocardial infarction elderly patients Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/761506feb1534991abb87dbb403bd1f0
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spelling	oai:doaj.org-article:761506feb1534991abb87dbb403bd1f02021-12-02T11:44:16ZAssociation between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction1178-1998https://doaj.org/article/761506feb1534991abb87dbb403bd1f02019-07-01T00:00:00Zhttps://www.dovepress.com/association-between-inflammation-based-prognostic-scores-and-in-hospit-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rui Wang,1 Xiaodan Wen,2 Cheng Huang,1 Yingcong Liang,1 Yujing Mo,1 Ling Xue11Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 2Department of Geriatrics, Guangdong Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of ChinaObjective: Emerging evidence suggests that systemic inflammation is a predictor of poor prognosis in acute myocardial infarction (AMI). In this study, we sought to assess whether inflammation-based prognostic scores are associated with in-hospital outcomes in elderly patients with AMI.Methods: In this retrospective study, patients who were over 75-years-old and met the diagnostic criteria for AMI were consecutively recruited from January 1, 2016, to March 31, 2019. Logistic regression and receiver-operating characteristic (ROC) analyses were performed to evaluate the predictive value of the inflammation-based Glasgow Prognostic Score (GPS), Prognostic Index (PI) and Prognostic Nutritional Index (PNI).Results: A total of 273 patients were enrolled. The incidence of major cardiovascular adverse events (MACEs) and mortality during hospitalization increased significantly with increasing GPS and PI scores. Multiple logistic regression showed that the GPS was independently associated with MACEs (score 1, RR: 6.711, 95% CI: 1.409–31.968; score 2, RR: 14.063, 95% CI: 3.018–65.535) and mortality (score 1, RR: 8.656, 95% CI: 1.068–70.126; score 2, RR: 10.549, 95% CI: 1.317–84.465). The PI was also independently predictive of MACEs (score 2, RR: 5.132, 95% CI: 1.451–18.148). No significant difference was observed in the PNI between patients with different in-hospital outcomes. When in-hospital MACEs were used as an endpoint, the area under the curve (AUC) of the GPS was 0.740 (95% CI 0.678–0.802), and the AUC of the PI was 0.703 (95% CI 0.634–0.773). When mortality was used as an endpoint, the AUC of the GPS was 0.677 (95% CI 0.602–0.753), and the AUC of the PI was 0.667 (95% CI 0.577–0.757).Conclusion: The severity of systemic inflammation is a strong predictor of poor prognosis in elderly patients with AMI. Among these three inflammation-based prognostic scores, the GPS has a better predictive value than the PI and PNI for in-hospital MACEs and mortality.Keywords: inflammation-based prognostic scores, acute myocardial infarction, elderly patientsWang RWen XHuang CLiang YMo YXue LDove Medical Pressarticleinflammation-based prognostic scoresacute myocardial infarctionelderly patientsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1199-1206 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation-based prognostic scores acute myocardial infarction elderly patients Geriatrics RC952-954.6
spellingShingle	inflammation-based prognostic scores acute myocardial infarction elderly patients Geriatrics RC952-954.6 Wang R Wen X Huang C Liang Y Mo Y Xue L Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
description	Rui Wang,1 Xiaodan Wen,2 Cheng Huang,1 Yingcong Liang,1 Yujing Mo,1 Ling Xue11Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 2Department of Geriatrics, Guangdong Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of ChinaObjective: Emerging evidence suggests that systemic inflammation is a predictor of poor prognosis in acute myocardial infarction (AMI). In this study, we sought to assess whether inflammation-based prognostic scores are associated with in-hospital outcomes in elderly patients with AMI.Methods: In this retrospective study, patients who were over 75-years-old and met the diagnostic criteria for AMI were consecutively recruited from January 1, 2016, to March 31, 2019. Logistic regression and receiver-operating characteristic (ROC) analyses were performed to evaluate the predictive value of the inflammation-based Glasgow Prognostic Score (GPS), Prognostic Index (PI) and Prognostic Nutritional Index (PNI).Results: A total of 273 patients were enrolled. The incidence of major cardiovascular adverse events (MACEs) and mortality during hospitalization increased significantly with increasing GPS and PI scores. Multiple logistic regression showed that the GPS was independently associated with MACEs (score 1, RR: 6.711, 95% CI: 1.409–31.968; score 2, RR: 14.063, 95% CI: 3.018–65.535) and mortality (score 1, RR: 8.656, 95% CI: 1.068–70.126; score 2, RR: 10.549, 95% CI: 1.317–84.465). The PI was also independently predictive of MACEs (score 2, RR: 5.132, 95% CI: 1.451–18.148). No significant difference was observed in the PNI between patients with different in-hospital outcomes. When in-hospital MACEs were used as an endpoint, the area under the curve (AUC) of the GPS was 0.740 (95% CI 0.678–0.802), and the AUC of the PI was 0.703 (95% CI 0.634–0.773). When mortality was used as an endpoint, the AUC of the GPS was 0.677 (95% CI 0.602–0.753), and the AUC of the PI was 0.667 (95% CI 0.577–0.757).Conclusion: The severity of systemic inflammation is a strong predictor of poor prognosis in elderly patients with AMI. Among these three inflammation-based prognostic scores, the GPS has a better predictive value than the PI and PNI for in-hospital MACEs and mortality.Keywords: inflammation-based prognostic scores, acute myocardial infarction, elderly patients
format	article
author	Wang R Wen X Huang C Liang Y Mo Y Xue L
author_facet	Wang R Wen X Huang C Liang Y Mo Y Xue L
author_sort	Wang R
title	Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
title_short	Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
title_full	Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
title_fullStr	Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
title_full_unstemmed	Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
title_sort	association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/761506feb1534991abb87dbb403bd1f0
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Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction

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