Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking

Membrane trafficking is all about time. Automation in such a biological process is crucial to ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared molecular regulators and differential engagement of trafficking components improve robustness of molecular sorting. S...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giampaolo Placidi, Carlo C. Campa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sorting endosome ESCRT retromer commander lipid rafts Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/76162494b55846a0856e047de0e86a9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76162494b55846a0856e047de0e86a9e
record_format	dspace
spelling	oai:doaj.org-article:76162494b55846a0856e047de0e86a9e2021-11-11T17:13:36ZDeliver on Time or Pay the Fine: Scheduling in Membrane Trafficking10.3390/ijms2221117731422-00671661-6596https://doaj.org/article/76162494b55846a0856e047de0e86a9e2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11773https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Membrane trafficking is all about time. Automation in such a biological process is crucial to ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared molecular regulators and differential engagement of trafficking components improve robustness of molecular sorting. Sequential recruitment of low affinity protein complexes ensures directionality of the process and, concomitantly, serves as a kinetic proofreading mechanism to discriminate cargoes from the whole endocytosed material. This strategy helps cells to minimize losses and operating errors in membrane trafficking, thereby matching the appealed deadline. Here, we summarize the molecular pathways of molecular sorting, focusing on their timing and efficacy. We also highlight experimental procedures and genetic approaches to robustly probe these pathways, in order to guide mechanistic studies at the interface between biochemistry and quantitative biology.Giampaolo PlacidiCarlo C. CampaMDPI AGarticlesortingendosomeESCRTretromercommanderlipid raftsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11773, p 11773 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sorting endosome ESCRT retromer commander lipid rafts Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sorting endosome ESCRT retromer commander lipid rafts Biology (General) QH301-705.5 Chemistry QD1-999 Giampaolo Placidi Carlo C. Campa Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
description	Membrane trafficking is all about time. Automation in such a biological process is crucial to ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared molecular regulators and differential engagement of trafficking components improve robustness of molecular sorting. Sequential recruitment of low affinity protein complexes ensures directionality of the process and, concomitantly, serves as a kinetic proofreading mechanism to discriminate cargoes from the whole endocytosed material. This strategy helps cells to minimize losses and operating errors in membrane trafficking, thereby matching the appealed deadline. Here, we summarize the molecular pathways of molecular sorting, focusing on their timing and efficacy. We also highlight experimental procedures and genetic approaches to robustly probe these pathways, in order to guide mechanistic studies at the interface between biochemistry and quantitative biology.
format	article
author	Giampaolo Placidi Carlo C. Campa
author_facet	Giampaolo Placidi Carlo C. Campa
author_sort	Giampaolo Placidi
title	Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
title_short	Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
title_full	Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
title_fullStr	Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
title_full_unstemmed	Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
title_sort	deliver on time or pay the fine: scheduling in membrane trafficking
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/76162494b55846a0856e047de0e86a9e
work_keys_str_mv	AT giampaoloplacidi deliverontimeorpaythefineschedulinginmembranetrafficking AT carloccampa deliverontimeorpaythefineschedulinginmembranetrafficking
_version_	1718432124780937216

Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking

Ejemplares similares