CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase acti...

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Autores principales:	Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/761b43ac125a4eb99158e2f0b22fb7cd
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spelling	oai:doaj.org-article:761b43ac125a4eb99158e2f0b22fb7cd2021-12-02T17:32:27ZCDK1 dependent phosphorylation of hTERT contributes to cancer progression10.1038/s41467-020-15289-72041-1723https://doaj.org/article/761b43ac125a4eb99158e2f0b22fb7cd2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15289-7https://doaj.org/toc/2041-1723Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase activities.Mami YasukawaYoshinari AndoTaro YamashitaYoko MatsudaShisako ShojiMasaki Suimye MoriokaHideya KawajiKumiko ShiozawaMitsuhiro MachitaniTakaya AbeShinji YamadaMika K. KanekoYukinari KatoYasuhide FurutaTadashi KondoMikako ShirouzuYoshihide HayashizakiShuichi KanekoKenkichi MasutomiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi CDK1 dependent phosphorylation of hTERT contributes to cancer progression
description	Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase activities.
format	article
author	Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi
author_facet	Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi
author_sort	Mami Yasukawa
title	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_short	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_full	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_fullStr	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_full_unstemmed	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_sort	cdk1 dependent phosphorylation of htert contributes to cancer progression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/761b43ac125a4eb99158e2f0b22fb7cd
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CDK1 dependent phosphorylation of hTERT contributes to cancer progression

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