MicroRNA-125b-5p mimic inhibits acute liver failure

miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.

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Autores principales:	Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/761b5ee823904e439bd2c21962dc3f7d
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spelling	oai:doaj.org-article:761b5ee823904e439bd2c21962dc3f7d2021-12-02T15:35:42ZMicroRNA-125b-5p mimic inhibits acute liver failure10.1038/ncomms119162041-1723https://doaj.org/article/761b5ee823904e439bd2c21962dc3f7d2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11916https://doaj.org/toc/2041-1723miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.Dakai YangQinggong YuanAsha BalakrishnanHeike BantelJan-Henning KlusmannMichael P. MannsMichael OttTobias CantzAmar Deep SharmaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dakai Yang Qinggong Yuan Asha Balakrishnan Heike Bantel Jan-Henning Klusmann Michael P. Manns Michael Ott Tobias Cantz Amar Deep Sharma MicroRNA-125b-5p mimic inhibits acute liver failure
description	miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.
format	article
author	Dakai Yang Qinggong Yuan Asha Balakrishnan Heike Bantel Jan-Henning Klusmann Michael P. Manns Michael Ott Tobias Cantz Amar Deep Sharma
author_facet	Dakai Yang Qinggong Yuan Asha Balakrishnan Heike Bantel Jan-Henning Klusmann Michael P. Manns Michael Ott Tobias Cantz Amar Deep Sharma
author_sort	Dakai Yang
title	MicroRNA-125b-5p mimic inhibits acute liver failure
title_short	MicroRNA-125b-5p mimic inhibits acute liver failure
title_full	MicroRNA-125b-5p mimic inhibits acute liver failure
title_fullStr	MicroRNA-125b-5p mimic inhibits acute liver failure
title_full_unstemmed	MicroRNA-125b-5p mimic inhibits acute liver failure
title_sort	microrna-125b-5p mimic inhibits acute liver failure
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/761b5ee823904e439bd2c21962dc3f7d
work_keys_str_mv	AT dakaiyang microrna125b5pmimicinhibitsacuteliverfailure AT qinggongyuan microrna125b5pmimicinhibitsacuteliverfailure AT ashabalakrishnan microrna125b5pmimicinhibitsacuteliverfailure AT heikebantel microrna125b5pmimicinhibitsacuteliverfailure AT janhenningklusmann microrna125b5pmimicinhibitsacuteliverfailure AT michaelpmanns microrna125b5pmimicinhibitsacuteliverfailure AT michaelott microrna125b5pmimicinhibitsacuteliverfailure AT tobiascantz microrna125b5pmimicinhibitsacuteliverfailure AT amardeepsharma microrna125b5pmimicinhibitsacuteliverfailure
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MicroRNA-125b-5p mimic inhibits acute liver failure

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