Altered sleep behavior in a genetic mouse model of impaired fear extinction

Abstract Sleep disturbances are a common complaint of anxiety patients and constitute a hallmark feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that poor sleep is not only a secondary symptom of anxiety- and trauma-related disorders but represents a risk factor in their...

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Autores principales:	Eva Maria Fritz, Matthias Kreuzer, Alp Altunkaya, Nicolas Singewald, Thomas Fenzl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/761b8f8d93844bb1bd67bb3a367b3968
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spelling	oai:doaj.org-article:761b8f8d93844bb1bd67bb3a367b39682021-12-02T13:41:43ZAltered sleep behavior in a genetic mouse model of impaired fear extinction10.1038/s41598-021-88475-22045-2322https://doaj.org/article/761b8f8d93844bb1bd67bb3a367b39682021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88475-2https://doaj.org/toc/2045-2322Abstract Sleep disturbances are a common complaint of anxiety patients and constitute a hallmark feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that poor sleep is not only a secondary symptom of anxiety- and trauma-related disorders but represents a risk factor in their development, for example by interfering with emotional memory processing. Fear extinction is a critical mechanism for the attenuation of fearful and traumatic memories and multiple studies suggest that healthy sleep is crucial for the formation of extinction memories. However, fear extinction is often impaired in anxiety- and trauma-related disorders—an endophenotype that is perfectly modelled in the 129S1/SvImJ inbred mouse strain. To investigate whether these mice exhibit altered sleep at baseline that could predispose them towards maladaptive fear processing, we compared their circadian sleep/wake patterns to those of typically extinction-competent C57BL/6 mice. We found significant differences regarding diurnal distribution of sleep and wakefulness, but also sleep architecture, spectral features and sleep spindle events. With regard to sleep disturbances reported by anxiety- and PTSD patients, our findings strengthen the 129S1/SvImJ mouse models’ face validity and highlight it as a platform to investigate novel, sleep-focused diagnostic and therapeutic strategies. Whether the identified alterations causally contribute to its pathological anxiety/PTSD-like phenotype will, however, have to be addressed in future studies.Eva Maria FritzMatthias KreuzerAlp AltunkayaNicolas SingewaldThomas FenzlNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Maria Fritz Matthias Kreuzer Alp Altunkaya Nicolas Singewald Thomas Fenzl Altered sleep behavior in a genetic mouse model of impaired fear extinction
description	Abstract Sleep disturbances are a common complaint of anxiety patients and constitute a hallmark feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that poor sleep is not only a secondary symptom of anxiety- and trauma-related disorders but represents a risk factor in their development, for example by interfering with emotional memory processing. Fear extinction is a critical mechanism for the attenuation of fearful and traumatic memories and multiple studies suggest that healthy sleep is crucial for the formation of extinction memories. However, fear extinction is often impaired in anxiety- and trauma-related disorders—an endophenotype that is perfectly modelled in the 129S1/SvImJ inbred mouse strain. To investigate whether these mice exhibit altered sleep at baseline that could predispose them towards maladaptive fear processing, we compared their circadian sleep/wake patterns to those of typically extinction-competent C57BL/6 mice. We found significant differences regarding diurnal distribution of sleep and wakefulness, but also sleep architecture, spectral features and sleep spindle events. With regard to sleep disturbances reported by anxiety- and PTSD patients, our findings strengthen the 129S1/SvImJ mouse models’ face validity and highlight it as a platform to investigate novel, sleep-focused diagnostic and therapeutic strategies. Whether the identified alterations causally contribute to its pathological anxiety/PTSD-like phenotype will, however, have to be addressed in future studies.
format	article
author	Eva Maria Fritz Matthias Kreuzer Alp Altunkaya Nicolas Singewald Thomas Fenzl
author_facet	Eva Maria Fritz Matthias Kreuzer Alp Altunkaya Nicolas Singewald Thomas Fenzl
author_sort	Eva Maria Fritz
title	Altered sleep behavior in a genetic mouse model of impaired fear extinction
title_short	Altered sleep behavior in a genetic mouse model of impaired fear extinction
title_full	Altered sleep behavior in a genetic mouse model of impaired fear extinction
title_fullStr	Altered sleep behavior in a genetic mouse model of impaired fear extinction
title_full_unstemmed	Altered sleep behavior in a genetic mouse model of impaired fear extinction
title_sort	altered sleep behavior in a genetic mouse model of impaired fear extinction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/761b8f8d93844bb1bd67bb3a367b3968
work_keys_str_mv	AT evamariafritz alteredsleepbehaviorinageneticmousemodelofimpairedfearextinction AT matthiaskreuzer alteredsleepbehaviorinageneticmousemodelofimpairedfearextinction AT alpaltunkaya alteredsleepbehaviorinageneticmousemodelofimpairedfearextinction AT nicolassingewald alteredsleepbehaviorinageneticmousemodelofimpairedfearextinction AT thomasfenzl alteredsleepbehaviorinageneticmousemodelofimpairedfearextinction
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Altered sleep behavior in a genetic mouse model of impaired fear extinction

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