Gene-environment dependencies lead to collider bias in models with polygenic scores

Abstract The application of polygenic scores has transformed our ability to investigate whether and how genetic and environmental factors jointly contribute to the variation of complex traits. Modelling the complex interplay between genes and environment, however, raises serious methodological chall...

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Bibliographic Details
Main Authors: Evelina T. Akimova, Richard Breen, David M. Brazel, Melinda C. Mills
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/761cc895c9364720913852b6f88955f3
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