Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

Ferial M Zeried, Uchechukwu L Osuagwu Department of Optometry and Vision Sciences College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia Purpose: To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal...

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Autores principales:	Zeried FM, Osuagwu UL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7626a15e83b5498c8a6ed4c68a0e3c37
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spelling	oai:doaj.org-article:7626a15e83b5498c8a6ed4c68a0e3c372021-12-02T01:21:12ZChanges in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects1177-54671177-5483https://doaj.org/article/7626a15e83b5498c8a6ed4c68a0e3c372013-09-01T00:00:00Zhttp://www.dovepress.com/changes-in-retinal-nerve-fiber-layer-and-optic-disc-algorithms-by-opti-a14499https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ferial M Zeried, Uchechukwu L Osuagwu Department of Optometry and Vision Sciences College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia Purpose: To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT). Methods: RNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups. Results: The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes (P < 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at 1 o’clock (43%) and 5 o’clock (40%) hour sectors. Significant differences were observed between glaucomatous and control eyes in all disc parameters (P < 0.005) assessed. The disc area, cup area, mean cup/disc ratio, and vertical and horizontal cup/disc ratios were significantly larger (P < 0.01), whereas the vertical integrated rim area, horizontal integrated rim width, and rim area were significantly smaller (P < 0.001) in glaucomatous eyes than in normal eyes. Conclusion: Stratus OCT is still a valuable tool in the diagnosis of early glaucoma changes and, as such, its use should be encouraged in glaucoma clinics in Saudi Arabia. The best OCT parameters for detecting early glaucoma change were RNFL thickness in the inferior, superior, and 1 o’clock hour sector; the cup area; and the vertical integrated rim area of the optic disc. Keywords: glaucoma, Stratus optical coherence tomography, optic disc, retinal nerve fiber layer (RNFL), age, Saudi ArabiaZeried FMOsuagwu ULDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1941-1949 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Zeried FM Osuagwu UL Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
description	Ferial M Zeried, Uchechukwu L Osuagwu Department of Optometry and Vision Sciences College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia Purpose: To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT). Methods: RNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups. Results: The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes (P < 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at 1 o’clock (43%) and 5 o’clock (40%) hour sectors. Significant differences were observed between glaucomatous and control eyes in all disc parameters (P < 0.005) assessed. The disc area, cup area, mean cup/disc ratio, and vertical and horizontal cup/disc ratios were significantly larger (P < 0.01), whereas the vertical integrated rim area, horizontal integrated rim width, and rim area were significantly smaller (P < 0.001) in glaucomatous eyes than in normal eyes. Conclusion: Stratus OCT is still a valuable tool in the diagnosis of early glaucoma changes and, as such, its use should be encouraged in glaucoma clinics in Saudi Arabia. The best OCT parameters for detecting early glaucoma change were RNFL thickness in the inferior, superior, and 1 o’clock hour sector; the cup area; and the vertical integrated rim area of the optic disc. Keywords: glaucoma, Stratus optical coherence tomography, optic disc, retinal nerve fiber layer (RNFL), age, Saudi Arabia
format	article
author	Zeried FM Osuagwu UL
author_facet	Zeried FM Osuagwu UL
author_sort	Zeried FM
title	Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
title_short	Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
title_full	Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
title_fullStr	Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
title_full_unstemmed	Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects
title_sort	changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous arab subjects
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7626a15e83b5498c8a6ed4c68a0e3c37
work_keys_str_mv	AT zeriedfm changesinretinalnervefiberlayerandopticdiscalgorithmsbyopticalcoherencetomographyinglaucomatousarabsubjects AT osuagwuul changesinretinalnervefiberlayerandopticdiscalgorithmsbyopticalcoherencetomographyinglaucomatousarabsubjects
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Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

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