Pathovar Transcriptomes

ABSTRACT Archetypal pathogenic bacterial strains are often used to elucidate regulatory networks of an entire pathovar, which encompasses multiple lineages and phylogroups. With enteropathogenic Escherichia coli (EPEC) as a model system, Hazen and colleagues (mSystems 6:e00024-17, 2017, https://doi....

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Autores principales:	Amy Platenkamp, Jay L. Mellies
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	diversity EPEC pathovar transcriptome genome analysis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7629435c6c3e4f21b769c4653c239c65
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spelling	oai:doaj.org-article:7629435c6c3e4f21b769c4653c239c652021-12-02T18:15:43ZPathovar Transcriptomes10.1128/mSystems.00049-172379-5077https://doaj.org/article/7629435c6c3e4f21b769c4653c239c652017-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00049-17https://doaj.org/toc/2379-5077ABSTRACT Archetypal pathogenic bacterial strains are often used to elucidate regulatory networks of an entire pathovar, which encompasses multiple lineages and phylogroups. With enteropathogenic Escherichia coli (EPEC) as a model system, Hazen and colleagues (mSystems 6:e00024-17, 2017, https://doi.org/10.1128/mSystems.00024-17 ) used 9 isolates representing 8 lineages and 3 phylogroups to find that isolates with similar genomic sequences exhibit similarities in global transcriptomes under conditions of growth in medium that induces virulence gene expression. They also found variation among individual isolates. Their work illustrates the importance of moving beyond observing regulatory phenomena of a limited number of regulons in a few archetypal strains, with the possibility of correlating clinical symptoms to key transcriptional pathways across lineages and phylogroups.Amy PlatenkampJay L. MelliesAmerican Society for MicrobiologyarticlediversityEPECpathovartranscriptomegenome analysisMicrobiologyQR1-502ENmSystems, Vol 2, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	diversity EPEC pathovar transcriptome genome analysis Microbiology QR1-502
spellingShingle	diversity EPEC pathovar transcriptome genome analysis Microbiology QR1-502 Amy Platenkamp Jay L. Mellies Pathovar Transcriptomes
description	ABSTRACT Archetypal pathogenic bacterial strains are often used to elucidate regulatory networks of an entire pathovar, which encompasses multiple lineages and phylogroups. With enteropathogenic Escherichia coli (EPEC) as a model system, Hazen and colleagues (mSystems 6:e00024-17, 2017, https://doi.org/10.1128/mSystems.00024-17 ) used 9 isolates representing 8 lineages and 3 phylogroups to find that isolates with similar genomic sequences exhibit similarities in global transcriptomes under conditions of growth in medium that induces virulence gene expression. They also found variation among individual isolates. Their work illustrates the importance of moving beyond observing regulatory phenomena of a limited number of regulons in a few archetypal strains, with the possibility of correlating clinical symptoms to key transcriptional pathways across lineages and phylogroups.
format	article
author	Amy Platenkamp Jay L. Mellies
author_facet	Amy Platenkamp Jay L. Mellies
author_sort	Amy Platenkamp
title	Pathovar Transcriptomes
title_short	Pathovar Transcriptomes
title_full	Pathovar Transcriptomes
title_fullStr	Pathovar Transcriptomes
title_full_unstemmed	Pathovar Transcriptomes
title_sort	pathovar transcriptomes
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/7629435c6c3e4f21b769c4653c239c65
work_keys_str_mv	AT amyplatenkamp pathovartranscriptomes AT jaylmellies pathovartranscriptomes
_version_	1718378340098768896

Pathovar Transcriptomes

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