Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery

Latrisha K Petersen,1 Lucas Huntimer,2 Katharine Walz,1 Amanda Ramer-Tait,2 Michael J Wannemuehler,2 Balaji Narasimhan11Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA; 2Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Petersen LK, Huntimer L, Walz K, Ramer-Tait A, Wannemuehler MJ, Narasimhan B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/762970708cc744ec8fce550e3172651d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:762970708cc744ec8fce550e3172651d
record_format	dspace
spelling	oai:doaj.org-article:762970708cc744ec8fce550e3172651d2021-12-02T00:43:05ZCombinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery1176-91141178-2013https://doaj.org/article/762970708cc744ec8fce550e3172651d2013-06-01T00:00:00Zhttp://www.dovepress.com/combinatorial-evaluation-of-in-vivo-distribution-of-polyanhydride-part-a13389https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Latrisha K Petersen,1 Lucas Huntimer,2 Katharine Walz,1 Amanda Ramer-Tait,2 Michael J Wannemuehler,2 Balaji Narasimhan11Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA; 2Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USAAbstract: Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants.Keywords: combinatorial, polyanhydride, nanoparticle, live animal imaging, distributionPetersen LKHuntimer LWalz KRamer-Tait AWannemuehler MJNarasimhan BDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2213-2225 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Petersen LK Huntimer L Walz K Ramer-Tait A Wannemuehler MJ Narasimhan B Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
description	Latrisha K Petersen,1 Lucas Huntimer,2 Katharine Walz,1 Amanda Ramer-Tait,2 Michael J Wannemuehler,2 Balaji Narasimhan11Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA; 2Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USAAbstract: Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants.Keywords: combinatorial, polyanhydride, nanoparticle, live animal imaging, distribution
format	article
author	Petersen LK Huntimer L Walz K Ramer-Tait A Wannemuehler MJ Narasimhan B
author_facet	Petersen LK Huntimer L Walz K Ramer-Tait A Wannemuehler MJ Narasimhan B
author_sort	Petersen LK
title	Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
title_short	Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
title_full	Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
title_fullStr	Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
title_full_unstemmed	Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
title_sort	combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/762970708cc744ec8fce550e3172651d
work_keys_str_mv	AT petersenlk combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery AT huntimerl combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery AT walzk combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery AT ramertaita combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery AT wannemuehlermj combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery AT narasimhanb combinatorialevaluationofinvivodistributionofpolyanhydrideparticlebasedplatformsforvaccinedelivery
_version_	1718403505124802560

Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery

Ejemplares similares