Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/762a6e8dd0c245dd8c980ced8121b927 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:762a6e8dd0c245dd8c980ced8121b927 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:762a6e8dd0c245dd8c980ced8121b9272021-12-02T14:40:54ZAlternative assembly of respiratory complex II connects energy stress to metabolic checkpoints10.1038/s41467-018-04603-z2041-1723https://doaj.org/article/762a6e8dd0c245dd8c980ced8121b9272018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04603-zhttps://doaj.org/toc/2041-1723Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.Ayenachew Bezawork-GeletaHe WenLanFeng DongBing YanJelena ViderStepana BoukalovaLinda KrobovaKaterina VanovaRenata ZobalovaMargarita SobolPavel HozakSilvia Magalhaes NovaisVeronika CaisovaPavel AbaffyRavindra NaraineYing PangThiri ZawPing ZhangRadek SindelkaMikael KubistaSteven ZurynMark P. MolloyMichael V. BerridgeKarel PacakJakub RohlenaSunghyouk ParkJiri NeuzilNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ayenachew Bezawork-Geleta He Wen LanFeng Dong Bing Yan Jelena Vider Stepana Boukalova Linda Krobova Katerina Vanova Renata Zobalova Margarita Sobol Pavel Hozak Silvia Magalhaes Novais Veronika Caisova Pavel Abaffy Ravindra Naraine Ying Pang Thiri Zaw Ping Zhang Radek Sindelka Mikael Kubista Steven Zuryn Mark P. Molloy Michael V. Berridge Karel Pacak Jakub Rohlena Sunghyouk Park Jiri Neuzil Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| description |
Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes. |
| format |
article |
| author |
Ayenachew Bezawork-Geleta He Wen LanFeng Dong Bing Yan Jelena Vider Stepana Boukalova Linda Krobova Katerina Vanova Renata Zobalova Margarita Sobol Pavel Hozak Silvia Magalhaes Novais Veronika Caisova Pavel Abaffy Ravindra Naraine Ying Pang Thiri Zaw Ping Zhang Radek Sindelka Mikael Kubista Steven Zuryn Mark P. Molloy Michael V. Berridge Karel Pacak Jakub Rohlena Sunghyouk Park Jiri Neuzil |
| author_facet |
Ayenachew Bezawork-Geleta He Wen LanFeng Dong Bing Yan Jelena Vider Stepana Boukalova Linda Krobova Katerina Vanova Renata Zobalova Margarita Sobol Pavel Hozak Silvia Magalhaes Novais Veronika Caisova Pavel Abaffy Ravindra Naraine Ying Pang Thiri Zaw Ping Zhang Radek Sindelka Mikael Kubista Steven Zuryn Mark P. Molloy Michael V. Berridge Karel Pacak Jakub Rohlena Sunghyouk Park Jiri Neuzil |
| author_sort |
Ayenachew Bezawork-Geleta |
| title |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| title_short |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| title_full |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| title_fullStr |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| title_full_unstemmed |
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints |
| title_sort |
alternative assembly of respiratory complex ii connects energy stress to metabolic checkpoints |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/762a6e8dd0c245dd8c980ced8121b927 |
| work_keys_str_mv |
AT ayenachewbezaworkgeleta alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT hewen alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT lanfengdong alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT bingyan alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT jelenavider alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT stepanaboukalova alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT lindakrobova alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT katerinavanova alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT renatazobalova alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT margaritasobol alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT pavelhozak alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT silviamagalhaesnovais alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT veronikacaisova alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT pavelabaffy alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT ravindranaraine alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT yingpang alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT thirizaw alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT pingzhang alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT radeksindelka alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT mikaelkubista alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT stevenzuryn alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT markpmolloy alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT michaelvberridge alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT karelpacak alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT jakubrohlena alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT sunghyoukpark alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints AT jirineuzil alternativeassemblyofrespiratorycomplexiiconnectsenergystresstometaboliccheckpoints |
| _version_ |
1718390118326206464 |