Probing the influence of mutations on FUS condensates, one molecule at a time

Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to st...

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Main Author:	Krishnananda Chattopadhyay
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/762ae43a100140e2ad6ddda9465b7a31
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spelling	oai:doaj.org-article:762ae43a100140e2ad6ddda9465b7a312021-12-02T15:07:32ZProbing the influence of mutations on FUS condensates, one molecule at a time10.1038/s42003-020-01560-62399-3642https://doaj.org/article/762ae43a100140e2ad6ddda9465b7a312021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01560-6https://doaj.org/toc/2399-3642Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.Krishnananda ChattopadhyayNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Krishnananda Chattopadhyay Probing the influence of mutations on FUS condensates, one molecule at a time
description	Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.
format	article
author	Krishnananda Chattopadhyay
author_facet	Krishnananda Chattopadhyay
author_sort	Krishnananda Chattopadhyay
title	Probing the influence of mutations on FUS condensates, one molecule at a time
title_short	Probing the influence of mutations on FUS condensates, one molecule at a time
title_full	Probing the influence of mutations on FUS condensates, one molecule at a time
title_fullStr	Probing the influence of mutations on FUS condensates, one molecule at a time
title_full_unstemmed	Probing the influence of mutations on FUS condensates, one molecule at a time
title_sort	probing the influence of mutations on fus condensates, one molecule at a time
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/762ae43a100140e2ad6ddda9465b7a31
work_keys_str_mv	AT krishnanandachattopadhyay probingtheinfluenceofmutationsonfuscondensatesonemoleculeatatime
_version_	1718388455884455936

Probing the influence of mutations on FUS condensates, one molecule at a time

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