LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA

Abstract. A study of leukocyte regulation system in a remission stage of bronchial asthma (BA) patients included following tests: CD-typing of lymphocytes, investigations in humoral and phagocytic mechanisms of immunity, evaluation of bronchoalveolar lavage characteristics, measurements of spontaneo...

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Autores principales:	L. V. Ryabova, A. V. Zurochka, S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma cd-typing bronchoalveolar lavage cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7631ced1c067403bb065b632d4cd53bf
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spelling	oai:doaj.org-article:7631ced1c067403bb065b632d4cd53bf2021-11-18T08:03:39ZLOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2009-2-3-169-176https://doaj.org/article/7631ced1c067403bb065b632d4cd53bf2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/285https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A study of leukocyte regulation system in a remission stage of bronchial asthma (BA) patients included following tests: CD-typing of lymphocytes, investigations in humoral and phagocytic mechanisms of immunity, evaluation of bronchoalveolar lavage characteristics, measurements of spontaneous production of IL-4, IL-1β, IL-10 and IFNγ cytokines in whole blood supernates and bronchoalveolar lavage, as compared with control samples. The first group represented mild-stage, mixed-type BA patients (both allergy- and infection-dependent), being in remission state. The second (control) group consisted of sixteen conditionally healthy patients.The results have shown that, even at early stages of BA development, some components of chronic inflammatory process are formed. They could be characterized as accumulation of different inflammatory cells, i.e., eosinophils, neutrophils, alveolar macrophages and monocytes at the local level. In parallel, some changes in T-, B-subpopulations and phagocytic compartment occur at systemic level. All these events comprise a basis for changes in type and quantity of the cytokines produced. It was established that the profile of cytokine secretion in peripheral blood is identical to the cytokine secretion profile in lung tissue.L. V. RyabovaA. V. ZurochkaS. V. KhaidukovSPb RAACIarticlebronchial asthmacd-typingbronchoalveolar lavagecytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 169-176 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma cd-typing bronchoalveolar lavage cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma cd-typing bronchoalveolar lavage cytokines Immunologic diseases. Allergy RC581-607 L. V. Ryabova A. V. Zurochka S. V. Khaidukov LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
description	Abstract. A study of leukocyte regulation system in a remission stage of bronchial asthma (BA) patients included following tests: CD-typing of lymphocytes, investigations in humoral and phagocytic mechanisms of immunity, evaluation of bronchoalveolar lavage characteristics, measurements of spontaneous production of IL-4, IL-1β, IL-10 and IFNγ cytokines in whole blood supernates and bronchoalveolar lavage, as compared with control samples. The first group represented mild-stage, mixed-type BA patients (both allergy- and infection-dependent), being in remission state. The second (control) group consisted of sixteen conditionally healthy patients.The results have shown that, even at early stages of BA development, some components of chronic inflammatory process are formed. They could be characterized as accumulation of different inflammatory cells, i.e., eosinophils, neutrophils, alveolar macrophages and monocytes at the local level. In parallel, some changes in T-, B-subpopulations and phagocytic compartment occur at systemic level. All these events comprise a basis for changes in type and quantity of the cytokines produced. It was established that the profile of cytokine secretion in peripheral blood is identical to the cytokine secretion profile in lung tissue.
format	article
author	L. V. Ryabova A. V. Zurochka S. V. Khaidukov
author_facet	L. V. Ryabova A. V. Zurochka S. V. Khaidukov
author_sort	L. V. Ryabova
title	LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
title_short	LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
title_full	LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
title_fullStr	LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
title_full_unstemmed	LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA
title_sort	local and systemic immune mechanisms of chronic inflammation in the patients with mild bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7631ced1c067403bb065b632d4cd53bf
work_keys_str_mv	AT lvryabova localandsystemicimmunemechanismsofchronicinflammationinthepatientswithmildbronchialasthma AT avzurochka localandsystemicimmunemechanismsofchronicinflammationinthepatientswithmildbronchialasthma AT svkhaidukov localandsystemicimmunemechanismsofchronicinflammationinthepatientswithmildbronchialasthma
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LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA

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