Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis.

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Autores principales:	Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/763387984e1f4e0ab862ad33d073b020
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spelling	oai:doaj.org-article:763387984e1f4e0ab862ad33d073b0202021-12-02T15:35:22ZImpact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair10.1038/ncomms108052041-1723https://doaj.org/article/763387984e1f4e0ab862ad33d073b0202016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10805https://doaj.org/toc/2041-1723Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis.Emmanuele CrespanAntonia FurrerMarcel RösingerFederica BertolettiElisa MentegariGiulia ChiappariniRalph ImhofNathalie ZieglerShana J. SturlaUlrich HübscherBarbara van LoonGiovanni MagaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanuele Crespan Antonia Furrer Marcel Rösinger Federica Bertoletti Elisa Mentegari Giulia Chiapparini Ralph Imhof Nathalie Ziegler Shana J. Sturla Ulrich Hübscher Barbara van Loon Giovanni Maga Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
description	Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis.
format	article
author	Emmanuele Crespan Antonia Furrer Marcel Rösinger Federica Bertoletti Elisa Mentegari Giulia Chiapparini Ralph Imhof Nathalie Ziegler Shana J. Sturla Ulrich Hübscher Barbara van Loon Giovanni Maga
author_facet	Emmanuele Crespan Antonia Furrer Marcel Rösinger Federica Bertoletti Elisa Mentegari Giulia Chiapparini Ralph Imhof Nathalie Ziegler Shana J. Sturla Ulrich Hübscher Barbara van Loon Giovanni Maga
author_sort	Emmanuele Crespan
title	Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
title_short	Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
title_full	Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
title_fullStr	Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
title_full_unstemmed	Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
title_sort	impact of ribonucleotide incorporation by dna polymerases β and λ on oxidative base excision repair
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/763387984e1f4e0ab862ad33d073b020
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Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

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