Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Jie Gao,1 Jun-Fa Xue,2 Meng Xu,2 Bao-Song Gui,1 Feng-Xin Wang,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan Unive...

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Autores principales:	Gao J, Xue JF, Xu M, Gui BS, Wang FX, Ouyang JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7635497f2d6a4596a0b5320f17648eda
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spelling	oai:doaj.org-article:7635497f2d6a4596a0b5320f17648eda2021-12-02T03:11:43ZNanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites1178-2013https://doaj.org/article/7635497f2d6a4596a0b5320f17648eda2014-09-01T00:00:00Zhttp://www.dovepress.com/nanouric-acid-or-nanocalcium-phosphate-as-central-nidus-to-induce-calc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Jie Gao,1 Jun-Fa Xue,2 Meng Xu,2 Bao-Song Gui,1 Feng-Xin Wang,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People’s Republic of ChinaPurpose: This study aimed to accurately analyze the relationship between calcium oxalate (CaOx) stone formation and the components of urinary nanocrystallites. Method: High-resolution transmission electron microscopy (HRTEM), selected area electron diffraction, fast Fourier transformation of HRTEM, and energy dispersive X-ray spectroscopy were performed to analyze the components of these nanocrystallites. Results: The main components of CaOx stones are calcium oxalate monohydrate and a small amount of dehydrate, while those of urinary nanocrystallites are calcium oxalate monohydrate, uric acid, and calcium phosphate. The mechanism of formation of CaOx stones was discussed based on the components of urinary nanocrystallites. Conclusion: The formation of CaOx stones is closely related both to the properties of urinary nanocrystallites and to the urinary components. The combination of HRTEM, fast Fourier transformation, selected area electron diffraction, and energy dispersive X-ray spectroscopy could be accurately performed to analyze the components of single urinary nanocrystallites. This result provides evidence for nanouric acid and/or nanocalcium phosphate crystallites as the central nidus to induce CaOx stone formation.Keywords: nanocrystallites, calcium oxalate stones, heterogeneous nucleation, HRTEM, EDSGao JXue JFXu MGui BSWang FXOuyang JMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4399-4409 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gao J Xue JF Xu M Gui BS Wang FX Ouyang JM Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
description	Jie Gao,1 Jun-Fa Xue,2 Meng Xu,2 Bao-Song Gui,1 Feng-Xin Wang,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People’s Republic of ChinaPurpose: This study aimed to accurately analyze the relationship between calcium oxalate (CaOx) stone formation and the components of urinary nanocrystallites. Method: High-resolution transmission electron microscopy (HRTEM), selected area electron diffraction, fast Fourier transformation of HRTEM, and energy dispersive X-ray spectroscopy were performed to analyze the components of these nanocrystallites. Results: The main components of CaOx stones are calcium oxalate monohydrate and a small amount of dehydrate, while those of urinary nanocrystallites are calcium oxalate monohydrate, uric acid, and calcium phosphate. The mechanism of formation of CaOx stones was discussed based on the components of urinary nanocrystallites. Conclusion: The formation of CaOx stones is closely related both to the properties of urinary nanocrystallites and to the urinary components. The combination of HRTEM, fast Fourier transformation, selected area electron diffraction, and energy dispersive X-ray spectroscopy could be accurately performed to analyze the components of single urinary nanocrystallites. This result provides evidence for nanouric acid and/or nanocalcium phosphate crystallites as the central nidus to induce CaOx stone formation.Keywords: nanocrystallites, calcium oxalate stones, heterogeneous nucleation, HRTEM, EDS
format	article
author	Gao J Xue JF Xu M Gui BS Wang FX Ouyang JM
author_facet	Gao J Xue JF Xu M Gui BS Wang FX Ouyang JM
author_sort	Gao J
title	Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
title_short	Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
title_full	Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
title_fullStr	Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
title_full_unstemmed	Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
title_sort	nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/7635497f2d6a4596a0b5320f17648eda
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Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

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