Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.

A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient...

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Autores principales: Manuel A F V Gonçalves, Maarten Holkers, Gijsbert P van Nierop, Roeland Wieringa, Maria G Pau, Antoine A F de Vries
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
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Acceso en línea:https://doaj.org/article/7635feeaf02b4cf78c72a82d7fbfa366
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