Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology

<h4>Background</h4> Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of proteomic profile of parotid (PA), submandibu...

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Autores principales:	Priscila Cunha Nascimento, Walessa Alana Bragança Aragão, Leonardo Oliveira Bittencourt, Aline Dionizio, Marilia A. R. Buzalaf, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/763761c6616243beab9b378b8821cfdd
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spelling	oai:doaj.org-article:763761c6616243beab9b378b8821cfdd2021-11-18T06:34:26ZMaternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology1932-6203https://doaj.org/article/763761c6616243beab9b378b8821cfdd2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575261/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of proteomic profile of parotid (PA), submandibular (SM), and sublingual (SL) glands of offspring rats. <h4>Materials and methods</h4> Pregnant Wistar rats were daily exposed to 40 μg/kg MeHg during both gestational and lactation periods. The proteomic profiles of the major salivary glands of the offspring rats were analyzed through mass spectrometry. <h4>Results</h4> The offspring rats exposed to MeHg showed significant alterations in the proteomic profiles of the PA, SM, and SL glands. Altered proteins were associated with cytoskeleton components, tissue morphogenesis, and response to stimulus and stress. <h4>Conclusion</h4> This original study showed that maternal MeHg exposure significantly modulates the expression of proteins and induces alterations in the proteomic profiles of developing salivary glands.Priscila Cunha NascimentoWalessa Alana Bragança AragãoLeonardo Oliveira BittencourtAline DionizioMarilia A. R. BuzalafMaria Elena Crespo-LopezRafael Rodrigues LimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Priscila Cunha Nascimento Walessa Alana Bragança Aragão Leonardo Oliveira Bittencourt Aline Dionizio Marilia A. R. Buzalaf Maria Elena Crespo-Lopez Rafael Rodrigues Lima Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
description	<h4>Background</h4> Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of proteomic profile of parotid (PA), submandibular (SM), and sublingual (SL) glands of offspring rats. <h4>Materials and methods</h4> Pregnant Wistar rats were daily exposed to 40 μg/kg MeHg during both gestational and lactation periods. The proteomic profiles of the major salivary glands of the offspring rats were analyzed through mass spectrometry. <h4>Results</h4> The offspring rats exposed to MeHg showed significant alterations in the proteomic profiles of the PA, SM, and SL glands. Altered proteins were associated with cytoskeleton components, tissue morphogenesis, and response to stimulus and stress. <h4>Conclusion</h4> This original study showed that maternal MeHg exposure significantly modulates the expression of proteins and induces alterations in the proteomic profiles of developing salivary glands.
format	article
author	Priscila Cunha Nascimento Walessa Alana Bragança Aragão Leonardo Oliveira Bittencourt Aline Dionizio Marilia A. R. Buzalaf Maria Elena Crespo-Lopez Rafael Rodrigues Lima
author_facet	Priscila Cunha Nascimento Walessa Alana Bragança Aragão Leonardo Oliveira Bittencourt Aline Dionizio Marilia A. R. Buzalaf Maria Elena Crespo-Lopez Rafael Rodrigues Lima
author_sort	Priscila Cunha Nascimento
title	Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
title_short	Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
title_full	Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
title_fullStr	Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
title_full_unstemmed	Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
title_sort	maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: prospects on translational toxicology
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/763761c6616243beab9b378b8821cfdd
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Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology

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