Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Human induced pluripotent stem cell (iPSC) cells have been used to model disease in specific cell types. Here, the authors develop an automated long-term culturing platform of human iPSC neurons, astrocytes, and microglia and use it to model some cellular aspects of Alzheimer’s disease.

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Detalles Bibliográficos
Autores principales:	Reina Bassil, Kenneth Shields, Kevin Granger, Ivan Zein, Shirley Ng, Ben Chih
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7638acaa151b4b4e94580ef337bbf292
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spelling	oai:doaj.org-article:7638acaa151b4b4e94580ef337bbf2922021-12-02T19:04:19ZImproved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia10.1038/s41467-021-25344-62041-1723https://doaj.org/article/7638acaa151b4b4e94580ef337bbf2922021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25344-6https://doaj.org/toc/2041-1723Human induced pluripotent stem cell (iPSC) cells have been used to model disease in specific cell types. Here, the authors develop an automated long-term culturing platform of human iPSC neurons, astrocytes, and microglia and use it to model some cellular aspects of Alzheimer’s disease.Reina BassilKenneth ShieldsKevin GrangerIvan ZeinShirley NgBen ChihNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reina Bassil Kenneth Shields Kevin Granger Ivan Zein Shirley Ng Ben Chih Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
description	Human induced pluripotent stem cell (iPSC) cells have been used to model disease in specific cell types. Here, the authors develop an automated long-term culturing platform of human iPSC neurons, astrocytes, and microglia and use it to model some cellular aspects of Alzheimer’s disease.
format	article
author	Reina Bassil Kenneth Shields Kevin Granger Ivan Zein Shirley Ng Ben Chih
author_facet	Reina Bassil Kenneth Shields Kevin Granger Ivan Zein Shirley Ng Ben Chih
author_sort	Reina Bassil
title	Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
title_short	Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
title_full	Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
title_fullStr	Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
title_full_unstemmed	Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
title_sort	improved modeling of human ad with an automated culturing platform for ipsc neurons, astrocytes and microglia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7638acaa151b4b4e94580ef337bbf292
work_keys_str_mv	AT reinabassil improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia AT kennethshields improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia AT kevingranger improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia AT ivanzein improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia AT shirleyng improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia AT benchih improvedmodelingofhumanadwithanautomatedculturingplatformforipscneuronsastrocytesandmicroglia
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Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

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