Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice

Abstract Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep...

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Autores principales:	Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/763901b7efb9492dab108daec0f52223
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spelling	oai:doaj.org-article:763901b7efb9492dab108daec0f522232021-12-02T15:22:57ZPain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice10.1038/s41598-021-93560-72045-2322https://doaj.org/article/763901b7efb9492dab108daec0f522232021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93560-7https://doaj.org/toc/2045-2322Abstract Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.Junhel DalanonSachiko ChikahisaTetsuya ShiuchiNoriyuki ShimizuParimal ChavanYoshitaka SuzukiKazuo OkuraHiroyoshi SéiYoshizo MatsukaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junhel Dalanon Sachiko Chikahisa Tetsuya Shiuchi Noriyuki Shimizu Parimal Chavan Yoshitaka Suzuki Kazuo Okura Hiroyoshi Séi Yoshizo Matsuka Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
description	Abstract Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.
format	article
author	Junhel Dalanon Sachiko Chikahisa Tetsuya Shiuchi Noriyuki Shimizu Parimal Chavan Yoshitaka Suzuki Kazuo Okura Hiroyoshi Séi Yoshizo Matsuka
author_facet	Junhel Dalanon Sachiko Chikahisa Tetsuya Shiuchi Noriyuki Shimizu Parimal Chavan Yoshitaka Suzuki Kazuo Okura Hiroyoshi Séi Yoshizo Matsuka
author_sort	Junhel Dalanon
title	Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
title_short	Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
title_full	Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
title_fullStr	Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
title_full_unstemmed	Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
title_sort	pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/763901b7efb9492dab108daec0f52223
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Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice

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