Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D

Abstract This animal study aimed to elucidate the relationship of low-dose, narrow-band UVB at 308 nm with vitamin D synthesis. C57BL/6 female mice, at 3 weeks-of-age, were randomly divided into the following six groups (n = 6 at each time point of vitamin D measurement), which were: (1) normal diet...

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Autores principales:	Ming-Yen Lin, Lee Moay Lim, Siao-Ping Tsai, Feng-Xuan Jian, Shang-Jyh Hwang, Yu-Hsuan Lin, Yi-Wen Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7639ddcb01aa48cfb9055f4e89b3edb4
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spelling	oai:doaj.org-article:7639ddcb01aa48cfb9055f4e89b3edb42021-12-02T14:16:49ZLow dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D10.1038/s41598-021-82216-12045-2322https://doaj.org/article/7639ddcb01aa48cfb9055f4e89b3edb42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82216-1https://doaj.org/toc/2045-2322Abstract This animal study aimed to elucidate the relationship of low-dose, narrow-band UVB at 308 nm with vitamin D synthesis. C57BL/6 female mice, at 3 weeks-of-age, were randomly divided into the following six groups (n = 6 at each time point of vitamin D measurement), which were: (1) normal diet without UVB irradiation; (2) VDd diet without UVB irradiation; and (3)–(6) VDd diet with 308 nm-UVB irradiation of 12.5, 25, 50, and 100 μω/cm2, respectively. All of the groups needing UVB irradiation received an exposure of 10 min per day, five days per week, and a duration of 3–5 weeks. The mice recovering from severe VDd (plasma total 25-hydroxyvitamin D level increasing from approximately 3 to over 30 ng/mL) only occurred in groups with a UVB irradiation dosage of either 50 or 100 μω/cm2. The optimal, estimated dosage for mice to recover from severe VDd was 355 mJ/cm2 within 3 weeks. Low-dose, narrow-band UVB irradiation at 308 nm is effective in improving VDd in mice. The results obtained, in addition to the especially small side effects of the above UVB irradiation formula, could be further translated to treating VDd-related disorders.Ming-Yen LinLee Moay LimSiao-Ping TsaiFeng-Xuan JianShang-Jyh HwangYu-Hsuan LinYi-Wen ChiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming-Yen Lin Lee Moay Lim Siao-Ping Tsai Feng-Xuan Jian Shang-Jyh Hwang Yu-Hsuan Lin Yi-Wen Chiu Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
description	Abstract This animal study aimed to elucidate the relationship of low-dose, narrow-band UVB at 308 nm with vitamin D synthesis. C57BL/6 female mice, at 3 weeks-of-age, were randomly divided into the following six groups (n = 6 at each time point of vitamin D measurement), which were: (1) normal diet without UVB irradiation; (2) VDd diet without UVB irradiation; and (3)–(6) VDd diet with 308 nm-UVB irradiation of 12.5, 25, 50, and 100 μω/cm2, respectively. All of the groups needing UVB irradiation received an exposure of 10 min per day, five days per week, and a duration of 3–5 weeks. The mice recovering from severe VDd (plasma total 25-hydroxyvitamin D level increasing from approximately 3 to over 30 ng/mL) only occurred in groups with a UVB irradiation dosage of either 50 or 100 μω/cm2. The optimal, estimated dosage for mice to recover from severe VDd was 355 mJ/cm2 within 3 weeks. Low-dose, narrow-band UVB irradiation at 308 nm is effective in improving VDd in mice. The results obtained, in addition to the especially small side effects of the above UVB irradiation formula, could be further translated to treating VDd-related disorders.
format	article
author	Ming-Yen Lin Lee Moay Lim Siao-Ping Tsai Feng-Xuan Jian Shang-Jyh Hwang Yu-Hsuan Lin Yi-Wen Chiu
author_facet	Ming-Yen Lin Lee Moay Lim Siao-Ping Tsai Feng-Xuan Jian Shang-Jyh Hwang Yu-Hsuan Lin Yi-Wen Chiu
author_sort	Ming-Yen Lin
title	Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
title_short	Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
title_full	Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
title_fullStr	Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
title_full_unstemmed	Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
title_sort	low dose ultraviolet b irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(oh)d
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7639ddcb01aa48cfb9055f4e89b3edb4
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Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D

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