Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Abstract E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. We have identified a list of p300-interacting proteins in human breast cancer cells. Among these, ELF5 was found to interact with p300 via acetylation...

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Autores principales:	Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/763b9e5df05043e0a6a0ddf5e84af082
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spelling	oai:doaj.org-article:763b9e5df05043e0a6a0ddf5e84af0822021-12-02T13:17:39ZAcetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND110.1038/s41698-021-00158-32397-768Xhttps://doaj.org/article/763b9e5df05043e0a6a0ddf5e84af0822021-03-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00158-3https://doaj.org/toc/2397-768XAbstract E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. We have identified a list of p300-interacting proteins in human breast cancer cells. Among these, ELF5 was found to interact with p300 via acetylation, and the potential acetylation sites were identified as K130, K134, K143, K197, K228, and K245. Furthermore, an ELF5-specific deacetylase, SIRT6, was also identified. Acetylation of ELF5 promoted its ubiquitination and degradation, but was also essential for its antiproliferative effect against breast cancer, as overexpression of wild-type ELF5 and sustained acetylation-mimicking ELF5 mutant could inhibit the expression of its target gene CCND1. Taken together, the results demonstrated a novel regulation of ELF5 as well as shedding light on its important role in modulation of breast cancer progression.Xiahui LiShujing LiBowen LiYanan LiSattout AmanKangkai XiaYuxi YangBashir AhmadHuijian WuNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiahui Li Shujing Li Bowen Li Yanan Li Sattout Aman Kangkai Xia Yuxi Yang Bashir Ahmad Huijian Wu Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
description	Abstract E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. We have identified a list of p300-interacting proteins in human breast cancer cells. Among these, ELF5 was found to interact with p300 via acetylation, and the potential acetylation sites were identified as K130, K134, K143, K197, K228, and K245. Furthermore, an ELF5-specific deacetylase, SIRT6, was also identified. Acetylation of ELF5 promoted its ubiquitination and degradation, but was also essential for its antiproliferative effect against breast cancer, as overexpression of wild-type ELF5 and sustained acetylation-mimicking ELF5 mutant could inhibit the expression of its target gene CCND1. Taken together, the results demonstrated a novel regulation of ELF5 as well as shedding light on its important role in modulation of breast cancer progression.
format	article
author	Xiahui Li Shujing Li Bowen Li Yanan Li Sattout Aman Kangkai Xia Yuxi Yang Bashir Ahmad Huijian Wu
author_facet	Xiahui Li Shujing Li Bowen Li Yanan Li Sattout Aman Kangkai Xia Yuxi Yang Bashir Ahmad Huijian Wu
author_sort	Xiahui Li
title	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
title_short	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
title_full	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
title_fullStr	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
title_full_unstemmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
title_sort	acetylation of elf5 suppresses breast cancer progression by promoting its degradation and targeting ccnd1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/763b9e5df05043e0a6a0ddf5e84af082
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Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

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