The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.

Cerebrovascular diseases are significant causes of death and disability in humans. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research. Ovine stroke models may represent a promising approach but...

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Autores principales: Anke Hoffmann, Michael H Stoffel, Björn Nitzsche, Donald Lobsien, Johannes Seeger, Holm Schneider, Johannes Boltze
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/763d72bbafd940e78d091b6cdfd02cbe
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spelling oai:doaj.org-article:763d72bbafd940e78d091b6cdfd02cbe2021-11-18T08:23:06ZThe ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.1932-620310.1371/journal.pone.0092990https://doaj.org/article/763d72bbafd940e78d091b6cdfd02cbe2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24736654/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cerebrovascular diseases are significant causes of death and disability in humans. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research. Ovine stroke models may represent a promising approach but are currently limited by insufficient knowledge regarding the venous system of the cerebral angioarchitecture. The present study was intended to provide a comprehensive anatomical analysis of the intracranial venous system in sheep as a reliable basis for the interpretation of experimental results in such ovine models. We used corrosion casts as well as contrast-enhanced magnetic resonance venography to scrutinize blood drainage from the brain. This combined approach yielded detailed and, to some extent, novel findings. In particular, we provide evidence for chordae Willisii and lateral venous lacunae, and report on connections between the dorsal and ventral sinuses in this species. For the first time, we also describe venous confluences in the deep cerebral venous system and an 'anterior condylar confluent' as seen in humans. This report provides a detailed reference for the interpretation of venous diagnostic imaging findings in sheep, including an assessment of structure detectability by in vivo (imaging) versus ex vivo (corrosion cast) visualization methods. Moreover, it features a comprehensive interspecies-comparison of the venous cerebral angioarchitecture in man, rodents, canines and sheep as a relevant large animal model species, and describes possible implications for translational cerebrovascular research.Anke HoffmannMichael H StoffelBjörn NitzscheDonald LobsienJohannes SeegerHolm SchneiderJohannes BoltzePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e92990 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Anke Hoffmann
Michael H Stoffel
Björn Nitzsche
Donald Lobsien
Johannes Seeger
Holm Schneider
Johannes Boltze
The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
description Cerebrovascular diseases are significant causes of death and disability in humans. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research. Ovine stroke models may represent a promising approach but are currently limited by insufficient knowledge regarding the venous system of the cerebral angioarchitecture. The present study was intended to provide a comprehensive anatomical analysis of the intracranial venous system in sheep as a reliable basis for the interpretation of experimental results in such ovine models. We used corrosion casts as well as contrast-enhanced magnetic resonance venography to scrutinize blood drainage from the brain. This combined approach yielded detailed and, to some extent, novel findings. In particular, we provide evidence for chordae Willisii and lateral venous lacunae, and report on connections between the dorsal and ventral sinuses in this species. For the first time, we also describe venous confluences in the deep cerebral venous system and an 'anterior condylar confluent' as seen in humans. This report provides a detailed reference for the interpretation of venous diagnostic imaging findings in sheep, including an assessment of structure detectability by in vivo (imaging) versus ex vivo (corrosion cast) visualization methods. Moreover, it features a comprehensive interspecies-comparison of the venous cerebral angioarchitecture in man, rodents, canines and sheep as a relevant large animal model species, and describes possible implications for translational cerebrovascular research.
format article
author Anke Hoffmann
Michael H Stoffel
Björn Nitzsche
Donald Lobsien
Johannes Seeger
Holm Schneider
Johannes Boltze
author_facet Anke Hoffmann
Michael H Stoffel
Björn Nitzsche
Donald Lobsien
Johannes Seeger
Holm Schneider
Johannes Boltze
author_sort Anke Hoffmann
title The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
title_short The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
title_full The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
title_fullStr The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
title_full_unstemmed The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
title_sort ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/763d72bbafd940e78d091b6cdfd02cbe
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