Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey

Aim. To study effect of sulodexide (Vessel Due F) on the functional state of endothelium in patients with diabetic retinopathy. Materials and methods. A total of 37 patients with DR were divided in 2 groups and treated with sulodexide. Group 1 comprised 16 patients withnon-proliferative DR, group...

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Autores principales:	Natalya Alexandrovna Gavrilova, Olga Evgen'evna Tishchenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	diabetic retinopathy sulodexide endothelial dysfunction endothelial factors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/763d89d135374d0196595cb522d8e73e
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spelling	oai:doaj.org-article:763d89d135374d0196595cb522d8e73e2021-11-14T09:00:16ZVliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey2072-03512072-037810.14341/2072-0351-5637https://doaj.org/article/763d89d135374d0196595cb522d8e73e2011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5637https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study effect of sulodexide (Vessel Due F) on the functional state of endothelium in patients with diabetic retinopathy. Materials and methods. A total of 37 patients with DR were divided in 2 groups and treated with sulodexide. Group 1 comprised 16 patients withnon-proliferative DR, group 2 included 21 patients with preproliferative DR. The functional state of endothelium was estimated from the plasma andserum levels of endothelial factors (sVCAM, endothelin, nitric oxide, t-PA, Willebrand factor). Results. The measurement of the initial levels of endothelial factors in both groups revealed significant changes in endothelin, nitric oxide, and sVCAMsuggesting disturbances of endothelial function due to DR. Sulodexide therapy normalized it regardless of DR stage and thereby improved functionalactivity of retina. Conclusion. This study has demonstrated beneficial effect of sulodexide on endothelial function in patients with DR due to correction of the productionof vasoactive factors (endothelin, nitric oxide) and stimulation of fibrinolytic activity of the vascular wall (t-PA).Natalya Alexandrovna GavrilovaOlga Evgen'evna TishchenkoEndocrinology Research Centrearticlediabetic retinopathysulodexideendothelial dysfunctionendothelial factorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 66-68 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic retinopathy sulodexide endothelial dysfunction endothelial factors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic retinopathy sulodexide endothelial dysfunction endothelial factors Nutritional diseases. Deficiency diseases RC620-627 Natalya Alexandrovna Gavrilova Olga Evgen'evna Tishchenko Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
description	Aim. To study effect of sulodexide (Vessel Due F) on the functional state of endothelium in patients with diabetic retinopathy. Materials and methods. A total of 37 patients with DR were divided in 2 groups and treated with sulodexide. Group 1 comprised 16 patients withnon-proliferative DR, group 2 included 21 patients with preproliferative DR. The functional state of endothelium was estimated from the plasma andserum levels of endothelial factors (sVCAM, endothelin, nitric oxide, t-PA, Willebrand factor). Results. The measurement of the initial levels of endothelial factors in both groups revealed significant changes in endothelin, nitric oxide, and sVCAMsuggesting disturbances of endothelial function due to DR. Sulodexide therapy normalized it regardless of DR stage and thereby improved functionalactivity of retina. Conclusion. This study has demonstrated beneficial effect of sulodexide on endothelial function in patients with DR due to correction of the productionof vasoactive factors (endothelin, nitric oxide) and stimulation of fibrinolytic activity of the vascular wall (t-PA).
format	article
author	Natalya Alexandrovna Gavrilova Olga Evgen'evna Tishchenko
author_facet	Natalya Alexandrovna Gavrilova Olga Evgen'evna Tishchenko
author_sort	Natalya Alexandrovna Gavrilova
title	Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
title_short	Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
title_full	Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
title_fullStr	Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
title_full_unstemmed	Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
title_sort	vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/763d89d135374d0196595cb522d8e73e
work_keys_str_mv	AT natalyaalexandrovnagavrilova vliyaniesulodeksidanafunktsionalnoesostoyanieendoteliyaubolnykhssakharnymdiabetomidiabeticheskoyretinopatiey AT olgaevgenevnatishchenko vliyaniesulodeksidanafunktsionalnoesostoyanieendoteliyaubolnykhssakharnymdiabetomidiabeticheskoyretinopatiey
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Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey

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