Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.

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Autores principales:	Sarah V. Faull, Andy M. C. Lau, Chloe Martens, Zainab Ahdash, Kjetil Hansen, Hugo Yebenes, Carla Schmidt, Fabienne Beuron, Nora B. Cronin, Edward P. Morris, Argyris Politis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/763dbdaeaef24615aa8b9632161a84b5
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spelling	oai:doaj.org-article:763dbdaeaef24615aa8b9632161a84b52021-12-02T17:01:47ZStructural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome10.1038/s41467-019-11772-y2041-1723https://doaj.org/article/763dbdaeaef24615aa8b9632161a84b52019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11772-yhttps://doaj.org/toc/2041-1723The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.Sarah V. FaullAndy M. C. LauChloe MartensZainab AhdashKjetil HansenHugo YebenesCarla SchmidtFabienne BeuronNora B. CroninEdward P. MorrisArgyris PolitisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah V. Faull Andy M. C. Lau Chloe Martens Zainab Ahdash Kjetil Hansen Hugo Yebenes Carla Schmidt Fabienne Beuron Nora B. Cronin Edward P. Morris Argyris Politis Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
description	The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.
format	article
author	Sarah V. Faull Andy M. C. Lau Chloe Martens Zainab Ahdash Kjetil Hansen Hugo Yebenes Carla Schmidt Fabienne Beuron Nora B. Cronin Edward P. Morris Argyris Politis
author_facet	Sarah V. Faull Andy M. C. Lau Chloe Martens Zainab Ahdash Kjetil Hansen Hugo Yebenes Carla Schmidt Fabienne Beuron Nora B. Cronin Edward P. Morris Argyris Politis
author_sort	Sarah V. Faull
title	Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
title_short	Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
title_full	Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
title_fullStr	Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
title_full_unstemmed	Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome
title_sort	structural basis of cullin 2 ring e3 ligase regulation by the cop9 signalosome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/763dbdaeaef24615aa8b9632161a84b5
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_version_	1718382034111430656

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

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