Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.

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Autores principales:	Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/763e7af1c632449592822f6a9fa2b319
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spelling	oai:doaj.org-article:763e7af1c632449592822f6a9fa2b3192021-12-02T14:41:21ZBik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria10.1038/s41467-017-00975-w2041-1723https://doaj.org/article/763e7af1c632449592822f6a9fa2b3192017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00975-whttps://doaj.org/toc/2041-1723Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.Yohannes A. MebratuIvan Leyva-BacaMarc G. WatheletNeal LaceyHitendra S. ChandAugustine M. K. ChoiYohannes TesfaigziNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yohannes A. Mebratu Ivan Leyva-Baca Marc G. Wathelet Neal Lacey Hitendra S. Chand Augustine M. K. Choi Yohannes Tesfaigzi Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
description	Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.
format	article
author	Yohannes A. Mebratu Ivan Leyva-Baca Marc G. Wathelet Neal Lacey Hitendra S. Chand Augustine M. K. Choi Yohannes Tesfaigzi
author_facet	Yohannes A. Mebratu Ivan Leyva-Baca Marc G. Wathelet Neal Lacey Hitendra S. Chand Augustine M. K. Choi Yohannes Tesfaigzi
author_sort	Yohannes A. Mebratu
title	Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
title_short	Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
title_full	Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
title_fullStr	Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
title_full_unstemmed	Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
title_sort	bik reduces hyperplastic cells by increasing bak and activating dapk1 to juxtapose er and mitochondria
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/763e7af1c632449592822f6a9fa2b319
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Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

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