Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics

Aim. To explore the recovery of the structure and density of the spongy and cortical bone after filling the defect with the bioglass developed by the authors. Material and Methods. The experiment was performed on white rats where the dynamics of blood biochemical markers were studied after implan...

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Autores principales:	V. Shymon, S. Alfeldii, M. Shymon, V. Stoyka
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2019
Materias:	bone, laboratory rats, bioglass Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7640861b61724f2b935dfcbe71b5262e
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spelling	oai:doaj.org-article:7640861b61724f2b935dfcbe71b5262e2021-11-10T19:49:51ZDynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics1029-42442415-330310.25040/aml2019.04.045https://doaj.org/article/7640861b61724f2b935dfcbe71b5262e2019-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/51https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To explore the recovery of the structure and density of the spongy and cortical bone after filling the defect with the bioglass developed by the authors. Material and Methods. The experiment was performed on white rats where the dynamics of blood biochemical markers were studied after implantation of glass-based and glass-ceramic materials. The study rats were divided into 2 groups. In the first group a material on the basis of glass ceramics AC-5 was implanted; in the second group - a material on the basis of glass FAR-5. Implant toxicity was determined based on the study of the dynamics of serum protein content, urea and alanine aminotransferase (ALT) enzyme activity. The state of restoration of the structure and density of the spongy and cortical bone was examined using alkaline phosphatase level. Results and Discussion. The study found no impact of implants based on glass ceramics AC-5 on the functional state of the liver and kidneys of experimental animals, but revealed the presence of inflammatory-regenerative changes in bone tissue at the implant site manifested only on day 7 of observation, which is normal regeneration after implantation. The dynamics of alkaline phosphatase activity in the serum of rats corresponded to the stages of bone regeneration and implant survival. In the rats of the second group, the content of total protein, unlike the animals of the first group, was significantly higher compared to the intact rats at all observation periods, indicating the presence of intoxication in animals. The glycoprotein content was increased, indicating the presence of inflammation in the animals at the end of the study. In contrast to the rats of the first group, the activity of alkaline phosphatase was significantly increased compared with that of the intact rats. The indicator increased with the observation period and returned to the reference values by the 90th day. Conclusion. Based on the study of the markers of bone metabolism (alkaline phosphatase activity and serum level of chondroitin sulfate ), a longer process of bone remodeling in case of implantation of the FAR-5 implant material was revealed, which increased compared to the test parameters of the intact animals.V. ShymonS. AlfeldiiM. ShymonV. StoykaDanylo Halytsky Lviv National Medical Universityarticlebone, laboratory rats, bioglassMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 25, Iss 4, Pp 45-49 (2019)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	bone, laboratory rats, bioglass Medicine (General) R5-920
spellingShingle	bone, laboratory rats, bioglass Medicine (General) R5-920 V. Shymon S. Alfeldii M. Shymon V. Stoyka Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
description	Aim. To explore the recovery of the structure and density of the spongy and cortical bone after filling the defect with the bioglass developed by the authors. Material and Methods. The experiment was performed on white rats where the dynamics of blood biochemical markers were studied after implantation of glass-based and glass-ceramic materials. The study rats were divided into 2 groups. In the first group a material on the basis of glass ceramics AC-5 was implanted; in the second group - a material on the basis of glass FAR-5. Implant toxicity was determined based on the study of the dynamics of serum protein content, urea and alanine aminotransferase (ALT) enzyme activity. The state of restoration of the structure and density of the spongy and cortical bone was examined using alkaline phosphatase level. Results and Discussion. The study found no impact of implants based on glass ceramics AC-5 on the functional state of the liver and kidneys of experimental animals, but revealed the presence of inflammatory-regenerative changes in bone tissue at the implant site manifested only on day 7 of observation, which is normal regeneration after implantation. The dynamics of alkaline phosphatase activity in the serum of rats corresponded to the stages of bone regeneration and implant survival. In the rats of the second group, the content of total protein, unlike the animals of the first group, was significantly higher compared to the intact rats at all observation periods, indicating the presence of intoxication in animals. The glycoprotein content was increased, indicating the presence of inflammation in the animals at the end of the study. In contrast to the rats of the first group, the activity of alkaline phosphatase was significantly increased compared with that of the intact rats. The indicator increased with the observation period and returned to the reference values by the 90th day. Conclusion. Based on the study of the markers of bone metabolism (alkaline phosphatase activity and serum level of chondroitin sulfate ), a longer process of bone remodeling in case of implantation of the FAR-5 implant material was revealed, which increased compared to the test parameters of the intact animals.
format	article
author	V. Shymon S. Alfeldii M. Shymon V. Stoyka
author_facet	V. Shymon S. Alfeldii M. Shymon V. Stoyka
author_sort	V. Shymon
title	Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
title_short	Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
title_full	Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
title_fullStr	Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
title_full_unstemmed	Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
title_sort	dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2019
url	https://doaj.org/article/7640861b61724f2b935dfcbe71b5262e
work_keys_str_mv	AT vshymon dynamicsoflaboratoryindicatorsofratsafterimplantationofbioglassmaterialandglassceramics AT salfeldii dynamicsoflaboratoryindicatorsofratsafterimplantationofbioglassmaterialandglassceramics AT mshymon dynamicsoflaboratoryindicatorsofratsafterimplantationofbioglassmaterialandglassceramics AT vstoyka dynamicsoflaboratoryindicatorsofratsafterimplantationofbioglassmaterialandglassceramics
_version_	1718439684693032960

Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics

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