Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis

Darin Sakiyalak, Yuwared Chattagoon Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to seve...

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Autores principales:	Sakiyalak D, Chattagoon Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ocular hypertension glaucoma keratitis corneal ulcer Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7640aed4c9c949c893d038bf61448ab4
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spelling	oai:doaj.org-article:7640aed4c9c949c893d038bf61448ab42021-12-02T07:35:29ZIncidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis1177-5483https://doaj.org/article/7640aed4c9c949c893d038bf61448ab42018-10-01T00:00:00Zhttps://www.dovepress.com/incidence-of-and-risk-factors-for-secondary-ocular-hypertension-in-mod-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Darin Sakiyalak, Yuwared Chattagoon Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT.Patients and methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted. Secondary OHT was defined as intraocular pressure (IOP) greater than 21 mmHg or a consistent demonstration of higher IOP in the affected eye of 8 mmHg or greater, at any time before resolution of the ulcer. The incidence of and the risk factors for secondary OHT were determined. Among the patients with secondary OHT, the incidence of and the risk factors for persistent elevated IOP and blindness at the last follow-up were also evaluated.Results: Two hundred and two eyes were included in the study. The incidence of secondary OHT was 45.5%. Severe keratitis and severe anterior chamber cells’ reaction were the risk factors for IOP elevation during active keratitis (P=0.003 and 0.018, respectively). Long-term data were available for 69 patients with OHT; 32.9% (22/69) developed persistent IOP elevation after keratitis resolved. Older age (P=0.007) and hyperosmotic agents used during active keratitis (P=0.028) were associated with persistent IOP elevation. Age was also associated with blindness among the patients with secondary OHT (P=0.002).Conclusion: Moderate to severe infectious keratitis was associated with a high incidence of secondary OHT. Two main risk factors were severe corneal infiltration and severe intraocular inflammation. One-third of the patients with OHT developed persistent elevated IOP after keratitis was healed. Older age and hyperosmotic agents used during active keratitis were significantly associated with persistent elevated IOP. Older age was also associated with poorer visual outcome. Keywords: intraocular pressure, glaucoma, keratitis, corneal ulcerSakiyalak DChattagoon YDove Medical Pressarticleocular hypertensionglaucomakeratitiscorneal ulcerOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2121-2128 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocular hypertension glaucoma keratitis corneal ulcer Ophthalmology RE1-994
spellingShingle	ocular hypertension glaucoma keratitis corneal ulcer Ophthalmology RE1-994 Sakiyalak D Chattagoon Y Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
description	Darin Sakiyalak, Yuwared Chattagoon Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT.Patients and methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted. Secondary OHT was defined as intraocular pressure (IOP) greater than 21 mmHg or a consistent demonstration of higher IOP in the affected eye of 8 mmHg or greater, at any time before resolution of the ulcer. The incidence of and the risk factors for secondary OHT were determined. Among the patients with secondary OHT, the incidence of and the risk factors for persistent elevated IOP and blindness at the last follow-up were also evaluated.Results: Two hundred and two eyes were included in the study. The incidence of secondary OHT was 45.5%. Severe keratitis and severe anterior chamber cells’ reaction were the risk factors for IOP elevation during active keratitis (P=0.003 and 0.018, respectively). Long-term data were available for 69 patients with OHT; 32.9% (22/69) developed persistent IOP elevation after keratitis resolved. Older age (P=0.007) and hyperosmotic agents used during active keratitis (P=0.028) were associated with persistent IOP elevation. Age was also associated with blindness among the patients with secondary OHT (P=0.002).Conclusion: Moderate to severe infectious keratitis was associated with a high incidence of secondary OHT. Two main risk factors were severe corneal infiltration and severe intraocular inflammation. One-third of the patients with OHT developed persistent elevated IOP after keratitis was healed. Older age and hyperosmotic agents used during active keratitis were significantly associated with persistent elevated IOP. Older age was also associated with poorer visual outcome. Keywords: intraocular pressure, glaucoma, keratitis, corneal ulcer
format	article
author	Sakiyalak D Chattagoon Y
author_facet	Sakiyalak D Chattagoon Y
author_sort	Sakiyalak D
title	Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
title_short	Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
title_full	Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
title_fullStr	Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
title_full_unstemmed	Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
title_sort	incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7640aed4c9c949c893d038bf61448ab4
work_keys_str_mv	AT sakiyalakd incidenceofandriskfactorsforsecondaryocularhypertensioninmoderatetosevereinfectiousulcerativekeratitis AT chattagoony incidenceofandriskfactorsforsecondaryocularhypertensioninmoderatetosevereinfectiousulcerativekeratitis
_version_	1718399345164812288

Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis

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