Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences

Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The...

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Autores principales: Tao Fan, Chunxiang Li, Jie He
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf
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spelling oai:doaj.org-article:76445aac66e94e7e853dd867bbb07baf2021-12-05T12:04:08ZPrognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences10.1186/s13293-021-00406-y2042-6410https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00406-yhttps://doaj.org/toc/2042-6410Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort.Tao FanChunxiang LiJie HeBMCarticleLung adenocarcinomaSex differencesTumor microenvironmentESTIMATE algorithmTumor-infiltrating immune cellsMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Lung adenocarcinoma
Sex differences
Tumor microenvironment
ESTIMATE algorithm
Tumor-infiltrating immune cells
Medicine
R
Physiology
QP1-981
spellingShingle Lung adenocarcinoma
Sex differences
Tumor microenvironment
ESTIMATE algorithm
Tumor-infiltrating immune cells
Medicine
R
Physiology
QP1-981
Tao Fan
Chunxiang Li
Jie He
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
description Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort.
format article
author Tao Fan
Chunxiang Li
Jie He
author_facet Tao Fan
Chunxiang Li
Jie He
author_sort Tao Fan
title Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_short Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_full Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_fullStr Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_full_unstemmed Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_sort prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
publisher BMC
publishDate 2021
url https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf
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AT chunxiangli prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences
AT jiehe prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences
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