Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The...
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2021
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oai:doaj.org-article:76445aac66e94e7e853dd867bbb07baf2021-12-05T12:04:08ZPrognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences10.1186/s13293-021-00406-y2042-6410https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00406-yhttps://doaj.org/toc/2042-6410Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort.Tao FanChunxiang LiJie HeBMCarticleLung adenocarcinomaSex differencesTumor microenvironmentESTIMATE algorithmTumor-infiltrating immune cellsMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-17 (2021) |
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Lung adenocarcinoma Sex differences Tumor microenvironment ESTIMATE algorithm Tumor-infiltrating immune cells Medicine R Physiology QP1-981 |
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Lung adenocarcinoma Sex differences Tumor microenvironment ESTIMATE algorithm Tumor-infiltrating immune cells Medicine R Physiology QP1-981 Tao Fan Chunxiang Li Jie He Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
description |
Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort. |
format |
article |
author |
Tao Fan Chunxiang Li Jie He |
author_facet |
Tao Fan Chunxiang Li Jie He |
author_sort |
Tao Fan |
title |
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
title_short |
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
title_full |
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
title_fullStr |
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
title_full_unstemmed |
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
title_sort |
prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences |
publisher |
BMC |
publishDate |
2021 |
url |
https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf |
work_keys_str_mv |
AT taofan prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences AT chunxiangli prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences AT jiehe prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences |
_version_ |
1718372262367723520 |