Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death

Abstract The forkhead box (Fox) genes encode transcription factors that control several key aspects of development. Present in the ancestor of all eukaryotes, Fox genes underwent several duplications followed by loss and diversification events that gave rise to the current 25 families. However, few...

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Autores principales:	Eudald Pascual-Carreras, Carlos Herrera-Úbeda, Maria Rosselló, Pablo Coronel-Córdoba, Jordi Garcia-Fernàndez, Emili Saló, Teresa Adell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76454b0ccdfc41718edb7fbbe43ffa46
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spelling	oai:doaj.org-article:76454b0ccdfc41718edb7fbbe43ffa462021-12-02T14:06:19ZAnalysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death10.1038/s41598-020-80627-02045-2322https://doaj.org/article/76454b0ccdfc41718edb7fbbe43ffa462021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80627-0https://doaj.org/toc/2045-2322Abstract The forkhead box (Fox) genes encode transcription factors that control several key aspects of development. Present in the ancestor of all eukaryotes, Fox genes underwent several duplications followed by loss and diversification events that gave rise to the current 25 families. However, few Fox members have been identified from the Lophotrochozoa clade, and specifically from planarians, which are a unique model for understanding development, due to the striking plasticity of the adult. The aim of this study was to identify and perform evolutionary and functional studies of the Fox genes of lophotrochozoan species and, specifically, of the planarian Schmidtea mediterranea. Generating a pipeline for identifying Forkhead domains and using phylogenetics allowed us the phylogenetic reconstruction of Fox genes. We corrected the annotation for misannotated genes and uncovered a new family, the QD, present in all metazoans. According to the new phylogeny, the 27 Fox genes found in Schmidtea mediterranea were classified into 12 families. In Platyhelminthes, family losses were accompanied by extensive gene diversification and the appearance of specific families, the A(P) and N(P). Among the newly identified planarian Fox genes, we found a single copy of foxO, which shows an evolutionary conserved role in controlling cell death.Eudald Pascual-CarrerasCarlos Herrera-ÚbedaMaria RossellóPablo Coronel-CórdobaJordi Garcia-FernàndezEmili SalóTeresa AdellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eudald Pascual-Carreras Carlos Herrera-Úbeda Maria Rosselló Pablo Coronel-Córdoba Jordi Garcia-Fernàndez Emili Saló Teresa Adell Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
description	Abstract The forkhead box (Fox) genes encode transcription factors that control several key aspects of development. Present in the ancestor of all eukaryotes, Fox genes underwent several duplications followed by loss and diversification events that gave rise to the current 25 families. However, few Fox members have been identified from the Lophotrochozoa clade, and specifically from planarians, which are a unique model for understanding development, due to the striking plasticity of the adult. The aim of this study was to identify and perform evolutionary and functional studies of the Fox genes of lophotrochozoan species and, specifically, of the planarian Schmidtea mediterranea. Generating a pipeline for identifying Forkhead domains and using phylogenetics allowed us the phylogenetic reconstruction of Fox genes. We corrected the annotation for misannotated genes and uncovered a new family, the QD, present in all metazoans. According to the new phylogeny, the 27 Fox genes found in Schmidtea mediterranea were classified into 12 families. In Platyhelminthes, family losses were accompanied by extensive gene diversification and the appearance of specific families, the A(P) and N(P). Among the newly identified planarian Fox genes, we found a single copy of foxO, which shows an evolutionary conserved role in controlling cell death.
format	article
author	Eudald Pascual-Carreras Carlos Herrera-Úbeda Maria Rosselló Pablo Coronel-Córdoba Jordi Garcia-Fernàndez Emili Saló Teresa Adell
author_facet	Eudald Pascual-Carreras Carlos Herrera-Úbeda Maria Rosselló Pablo Coronel-Córdoba Jordi Garcia-Fernàndez Emili Saló Teresa Adell
author_sort	Eudald Pascual-Carreras
title	Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
title_short	Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
title_full	Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
title_fullStr	Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
title_full_unstemmed	Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death
title_sort	analysis of fox genes in schmidtea mediterranea reveals new families and a conserved role of smed-foxo in controlling cell death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76454b0ccdfc41718edb7fbbe43ffa46
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Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death

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