Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water

Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water

Dynamic nuclear polarization (DNP) greatly improves the NMR sensitivity, but its implementation in aqueous solutions is challenging. Here the authors demonstrate carbon polarization enhancement via in situ Overhauser DNP in small biomolecules in water at room temperature and high magnetic field.

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Autores principales: Danhua Dai, Xianwei Wang, Yiwei Liu, Xiao-Liang Yang, Clemens Glaubitz, Vasyl Denysenkov, Xiao He, Thomas Prisner, Jiafei Mao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/76463244aa614a208775a3bdb5440d0f
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spelling oai:doaj.org-article:76463244aa614a208775a3bdb5440d0f2021-11-28T12:35:59ZRoom-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water10.1038/s41467-021-27067-02041-1723https://doaj.org/article/76463244aa614a208775a3bdb5440d0f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27067-0https://doaj.org/toc/2041-1723Dynamic nuclear polarization (DNP) greatly improves the NMR sensitivity, but its implementation in aqueous solutions is challenging. Here the authors demonstrate carbon polarization enhancement via in situ Overhauser DNP in small biomolecules in water at room temperature and high magnetic field.Danhua DaiXianwei WangYiwei LiuXiao-Liang YangClemens GlaubitzVasyl DenysenkovXiao HeThomas PrisnerJiafei MaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Danhua Dai
Xianwei Wang
Yiwei Liu
Xiao-Liang Yang
Clemens Glaubitz
Vasyl Denysenkov
Xiao He
Thomas Prisner
Jiafei Mao
Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
description Dynamic nuclear polarization (DNP) greatly improves the NMR sensitivity, but its implementation in aqueous solutions is challenging. Here the authors demonstrate carbon polarization enhancement via in situ Overhauser DNP in small biomolecules in water at room temperature and high magnetic field.
format article
author Danhua Dai
Xianwei Wang
Yiwei Liu
Xiao-Liang Yang
Clemens Glaubitz
Vasyl Denysenkov
Xiao He
Thomas Prisner
Jiafei Mao
author_facet Danhua Dai
Xianwei Wang
Yiwei Liu
Xiao-Liang Yang
Clemens Glaubitz
Vasyl Denysenkov
Xiao He
Thomas Prisner
Jiafei Mao
author_sort Danhua Dai
title Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
title_short Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
title_full Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
title_fullStr Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
title_full_unstemmed Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
title_sort room-temperature dynamic nuclear polarization enhanced nmr spectroscopy of small biological molecules in water
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/76463244aa614a208775a3bdb5440d0f
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