Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms

Nanoparticles (25–50 nm) of chemically modified calcium phosphates Ca10−x−y Mii xNay(PO4)6−z (CO3)z(OH)2 (Mii – Cu2+, Zn2+) were synthesized via a wet precipitation method at room temperature. The Fourier-transform infrared spectroscopy data confirmed the...

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Autores principales:	Grynyuk Iryna I., Vasyliuk Olga M., Prylutska Svitlana V., Strutynska Nataliia Yu., Livitska Oksana V., Slobodyanik Mykola S.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	apatite nanoparticles biofilm formation staphylococcus aureus pseudomonas aeruginosa Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7646e8b3d30d4938b6007a9c5a7cb4a2
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spelling	oai:doaj.org-article:7646e8b3d30d4938b6007a9c5a7cb4a22021-12-05T14:10:44ZInfluence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms2391-542010.1515/chem-2021-0199https://doaj.org/article/7646e8b3d30d4938b6007a9c5a7cb4a22021-02-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0199https://doaj.org/toc/2391-5420Nanoparticles (25–50 nm) of chemically modified calcium phosphates Ca10−x−y Mii xNay(PO4)6−z (CO3)z(OH)2 (Mii – Cu2+, Zn2+) were synthesized via a wet precipitation method at room temperature. The Fourier-transform infrared spectroscopy data confirmed the partial substitution of PO43−{\text{PO}}_{4}^{3-} → CO32−{\text{CO}}_{3}^{2-} (B-type) in apatite-type structure. The influence of prepared phosphates on biofilm formation by pathogenic microorganisms was investigated. It was found that the samples Na+, CO32−{\text{CO}}_{3}^{2-}-hydroxyapatite (HAP) and Na+, Zn2+, CO32−{\text{CO}}_{3}^{2-}-HAP (5–20 mM) had the highest inhibitory effect on biofilm formation by Staphylococcus aureus strains. The sample Na+, CO32−{\text{CO}}_{3}^{2-}-HAP had the slight influence on the formation of the biofilm by Pseudomonas aeruginosa, while for the samples Na+, Cu2+, CO32−{\text{CO}}_{3}^{2-}-HAP and Na+, Zn2+, CO32−{\text{CO}}_{3}^{2-}-HAP such an effect was not detected. According to transmission electron microscopy data, a correlation between the activity of synthesized apatite-related modified calcium phosphates in the processes of biofilm formation and their ability to adhere to the surface of bacterial cells was established. The prepared samples can be used for the design of effective materials with antibacterial activity for medicine.Grynyuk Iryna I.Vasyliuk Olga M.Prylutska Svitlana V.Strutynska Nataliia Yu.Livitska Oksana V.Slobodyanik Mykola S.De Gruyterarticleapatitenanoparticlesbiofilm formationstaphylococcus aureuspseudomonas aeruginosaChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 39-48 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apatite nanoparticles biofilm formation staphylococcus aureus pseudomonas aeruginosa Chemistry QD1-999
spellingShingle	apatite nanoparticles biofilm formation staphylococcus aureus pseudomonas aeruginosa Chemistry QD1-999 Grynyuk Iryna I. Vasyliuk Olga M. Prylutska Svitlana V. Strutynska Nataliia Yu. Livitska Oksana V. Slobodyanik Mykola S. Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
description	Nanoparticles (25–50 nm) of chemically modified calcium phosphates Ca10−x−y Mii xNay(PO4)6−z (CO3)z(OH)2 (Mii – Cu2+, Zn2+) were synthesized via a wet precipitation method at room temperature. The Fourier-transform infrared spectroscopy data confirmed the partial substitution of PO43−{\text{PO}}_{4}^{3-} → CO32−{\text{CO}}_{3}^{2-} (B-type) in apatite-type structure. The influence of prepared phosphates on biofilm formation by pathogenic microorganisms was investigated. It was found that the samples Na+, CO32−{\text{CO}}_{3}^{2-}-hydroxyapatite (HAP) and Na+, Zn2+, CO32−{\text{CO}}_{3}^{2-}-HAP (5–20 mM) had the highest inhibitory effect on biofilm formation by Staphylococcus aureus strains. The sample Na+, CO32−{\text{CO}}_{3}^{2-}-HAP had the slight influence on the formation of the biofilm by Pseudomonas aeruginosa, while for the samples Na+, Cu2+, CO32−{\text{CO}}_{3}^{2-}-HAP and Na+, Zn2+, CO32−{\text{CO}}_{3}^{2-}-HAP such an effect was not detected. According to transmission electron microscopy data, a correlation between the activity of synthesized apatite-related modified calcium phosphates in the processes of biofilm formation and their ability to adhere to the surface of bacterial cells was established. The prepared samples can be used for the design of effective materials with antibacterial activity for medicine.
format	article
author	Grynyuk Iryna I. Vasyliuk Olga M. Prylutska Svitlana V. Strutynska Nataliia Yu. Livitska Oksana V. Slobodyanik Mykola S.
author_facet	Grynyuk Iryna I. Vasyliuk Olga M. Prylutska Svitlana V. Strutynska Nataliia Yu. Livitska Oksana V. Slobodyanik Mykola S.
author_sort	Grynyuk Iryna I.
title	Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
title_short	Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
title_full	Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
title_fullStr	Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
title_full_unstemmed	Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
title_sort	influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/7646e8b3d30d4938b6007a9c5a7cb4a2
work_keys_str_mv	AT grynyukirynai influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms AT vasyliukolgam influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms AT prylutskasvitlanav influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms AT strutynskanataliiayu influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms AT livitskaoksanav influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms AT slobodyanikmykolas influenceofnanoscalemodifiedapatitetypecalciumphosphatesonthebiofilmformationbypathogenicmicroorganisms
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Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms

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