Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation

Cisplatin (CP) is one of the most effective chemotherapeutic drugs used to treat different tumors. Vitexin (VIT) is a natural flavonoid having various pharmacological activities along with its curative effects. The present research was planned to evaluate the therapeutic potential of VIT on cisplati...

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Autores principales:	Muhammad Umar Ijaz, Hussain Ahmed, Asma Ashraf, Sidra Aziz, K.A. Al-Ghanim, Mumtaz Akhtar, M. Nadeem Riaz, Shahid Mahboob
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cisplatin Nephrotoxicity Vitexin Flavonoid Curative potential Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/764a5bc57840419d9ace2500979e0095
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spelling	oai:doaj.org-article:764a5bc57840419d9ace2500979e00952021-11-18T04:44:27ZVitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation1018-364710.1016/j.jksus.2021.101657https://doaj.org/article/764a5bc57840419d9ace2500979e00952021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003190https://doaj.org/toc/1018-3647Cisplatin (CP) is one of the most effective chemotherapeutic drugs used to treat different tumors. Vitexin (VIT) is a natural flavonoid having various pharmacological activities along with its curative effects. The present research was planned to evaluate the therapeutic potential of VIT on cisplatin-induced renal damage in male albino rats. Twenty-four male albino rats were divided into four equal groups. These groups were treated with CP (10 mg/kg injection on the first day of trial) administered group, cotreated (CP; 10 mg/kg + VIT; 10 mg/kg) and only VIT (10 mg/kg orally till the end of the trial) treated group and a control. CP administration significantly decreased the activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), glutathione S-transferase (GST), glutathione (GSH), and glutathione reductase (GSR). The levels of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (H2O2) were increased. CP-treatment significantly increased the levels of urea, creatinine, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) while considerably reducing the creatinine clearance. The results demonstrated that CP significantly increased the inflammation markers, including tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) levels and cyclooxygenase-2 (COX-2) activities and histopathological damages. However, co-treatment with VIT efficiently minimized the CP-induced biochemical, inflammatory, and histopathological impairments in rat kidneys. The study's outcomes indicated the significant curative efficacy of VIT to overcome CP-induced nephrotoxicity in male albino rats.Muhammad Umar IjazHussain AhmedAsma AshrafSidra AzizK.A. Al-GhanimMumtaz AkhtarM. Nadeem RiazShahid MahboobElsevierarticleCisplatinNephrotoxicityVitexinFlavonoidCurative potentialScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101657- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin Nephrotoxicity Vitexin Flavonoid Curative potential Science (General) Q1-390
spellingShingle	Cisplatin Nephrotoxicity Vitexin Flavonoid Curative potential Science (General) Q1-390 Muhammad Umar Ijaz Hussain Ahmed Asma Ashraf Sidra Aziz K.A. Al-Ghanim Mumtaz Akhtar M. Nadeem Riaz Shahid Mahboob Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
description	Cisplatin (CP) is one of the most effective chemotherapeutic drugs used to treat different tumors. Vitexin (VIT) is a natural flavonoid having various pharmacological activities along with its curative effects. The present research was planned to evaluate the therapeutic potential of VIT on cisplatin-induced renal damage in male albino rats. Twenty-four male albino rats were divided into four equal groups. These groups were treated with CP (10 mg/kg injection on the first day of trial) administered group, cotreated (CP; 10 mg/kg + VIT; 10 mg/kg) and only VIT (10 mg/kg orally till the end of the trial) treated group and a control. CP administration significantly decreased the activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), glutathione S-transferase (GST), glutathione (GSH), and glutathione reductase (GSR). The levels of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (H2O2) were increased. CP-treatment significantly increased the levels of urea, creatinine, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) while considerably reducing the creatinine clearance. The results demonstrated that CP significantly increased the inflammation markers, including tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) levels and cyclooxygenase-2 (COX-2) activities and histopathological damages. However, co-treatment with VIT efficiently minimized the CP-induced biochemical, inflammatory, and histopathological impairments in rat kidneys. The study's outcomes indicated the significant curative efficacy of VIT to overcome CP-induced nephrotoxicity in male albino rats.
format	article
author	Muhammad Umar Ijaz Hussain Ahmed Asma Ashraf Sidra Aziz K.A. Al-Ghanim Mumtaz Akhtar M. Nadeem Riaz Shahid Mahboob
author_facet	Muhammad Umar Ijaz Hussain Ahmed Asma Ashraf Sidra Aziz K.A. Al-Ghanim Mumtaz Akhtar M. Nadeem Riaz Shahid Mahboob
author_sort	Muhammad Umar Ijaz
title	Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
title_short	Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
title_full	Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
title_fullStr	Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
title_full_unstemmed	Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
title_sort	vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/764a5bc57840419d9ace2500979e0095
work_keys_str_mv	AT muhammadumarijaz vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT hussainahmed vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT asmaashraf vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT sidraaziz vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT kaalghanim vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT mumtazakhtar vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT mnadeemriaz vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation AT shahidmahboob vitexinattenuatescisplatininducedrenaltoxicitybyreducingoxidativestressandinflammation
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Vitexin attenuates cisplatin-induced renal toxicity by reducing oxidative stress and inflammation

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