The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU

Abstract Preliminary data have produced conflicting results regarding whether initial vitamin C levels in patients with severe sepsis correlate with mortality outcomes. We hypothesized that low plasma ascorbic acid or thiamine levels in severe sepsis patients admitted from the Emergency Department (...

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Autores principales: Nandan Prasad, Anne V. Grossestreuer, Nuala J. Meyer, Sarah M. Perman, Mark E. Mikkelsen, Judd Hollander, David F. Gaieski
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:764ada0f89c144f69281d718d87744bb2021-12-02T16:50:24ZThe relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU10.1038/s41598-021-94473-12045-2322https://doaj.org/article/764ada0f89c144f69281d718d87744bb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94473-1https://doaj.org/toc/2045-2322Abstract Preliminary data have produced conflicting results regarding whether initial vitamin C levels in patients with severe sepsis correlate with mortality outcomes. We hypothesized that low plasma ascorbic acid or thiamine levels in severe sepsis patients admitted from the Emergency Department (ED) to the Intensive Care Unit (ICU) would be associated with increased mortality and an increased incidence of shock. Retrospective analysis of a prospective database of severe sepsis patients admitted to the ICU at an urban, academic medical center. Ascorbic acid and thiamine levels were analyzed in relation to survivors vs. non-survivors and shock vs. non-shock patients. 235 patients were included; mean age, 59.4 years ± 16.8 years; male, 128 (54.5%); in-hospital mortality, 16.6% (39/235); mean APACHE3 score, 61.8 ± 22.8; mean ascorbic acid level (reference range 0.40–2.10 mg/dL), 0.23 mg/dL (95% CI 0.07–4.02); and the mean thiamine level (reference range 14.6–29.5 nmol/L), 6.0 nmol/L (95% CI 4.0–9.5). When survivors were compared to non-survivors, survivors were more likely to be male (57.7% [113/196] vs. 38.5% [15/39]) and have lower APACHE3 scores (58.2 ± 22.6 vs. 79.9 ± 16.0). For the total cohort of 235 patients, there was no statistically significant relationship between a patient’s initial ascorbic acid or thiamine level and either survival or development of shock. In this analysis of early plasma samples from patients with severe sepsis admitted from the ED to the ICU, we found that mean ascorbic acid and thiamine levels were lower than normal range but that there was no relationship between these levels and outcomes, including 28 day mortality and development of shock.Nandan PrasadAnne V. GrossestreuerNuala J. MeyerSarah M. PermanMark E. MikkelsenJudd HollanderDavid F. GaieskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nandan Prasad
Anne V. Grossestreuer
Nuala J. Meyer
Sarah M. Perman
Mark E. Mikkelsen
Judd Hollander
David F. Gaieski
The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
description Abstract Preliminary data have produced conflicting results regarding whether initial vitamin C levels in patients with severe sepsis correlate with mortality outcomes. We hypothesized that low plasma ascorbic acid or thiamine levels in severe sepsis patients admitted from the Emergency Department (ED) to the Intensive Care Unit (ICU) would be associated with increased mortality and an increased incidence of shock. Retrospective analysis of a prospective database of severe sepsis patients admitted to the ICU at an urban, academic medical center. Ascorbic acid and thiamine levels were analyzed in relation to survivors vs. non-survivors and shock vs. non-shock patients. 235 patients were included; mean age, 59.4 years ± 16.8 years; male, 128 (54.5%); in-hospital mortality, 16.6% (39/235); mean APACHE3 score, 61.8 ± 22.8; mean ascorbic acid level (reference range 0.40–2.10 mg/dL), 0.23 mg/dL (95% CI 0.07–4.02); and the mean thiamine level (reference range 14.6–29.5 nmol/L), 6.0 nmol/L (95% CI 4.0–9.5). When survivors were compared to non-survivors, survivors were more likely to be male (57.7% [113/196] vs. 38.5% [15/39]) and have lower APACHE3 scores (58.2 ± 22.6 vs. 79.9 ± 16.0). For the total cohort of 235 patients, there was no statistically significant relationship between a patient’s initial ascorbic acid or thiamine level and either survival or development of shock. In this analysis of early plasma samples from patients with severe sepsis admitted from the ED to the ICU, we found that mean ascorbic acid and thiamine levels were lower than normal range but that there was no relationship between these levels and outcomes, including 28 day mortality and development of shock.
format article
author Nandan Prasad
Anne V. Grossestreuer
Nuala J. Meyer
Sarah M. Perman
Mark E. Mikkelsen
Judd Hollander
David F. Gaieski
author_facet Nandan Prasad
Anne V. Grossestreuer
Nuala J. Meyer
Sarah M. Perman
Mark E. Mikkelsen
Judd Hollander
David F. Gaieski
author_sort Nandan Prasad
title The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
title_short The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
title_full The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
title_fullStr The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
title_full_unstemmed The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU
title_sort relationship between vitamin c or thiamine levels and outcomes for severe sepsis patients admitted to the icu
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/764ada0f89c144f69281d718d87744bb
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