CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME

Abstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activi...

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Autores principales:	S. V. Plotnikova, L. F. Aznabaeva, G. Sh. Safuanova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutrophils monocytes differentiation clusters acute leukemia infectious complications Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/764cb34163d343b488bfa3108d381f16
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spelling	oai:doaj.org-article:764cb34163d343b488bfa3108d381f162021-11-18T08:03:43ZCHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME1563-06252313-741X10.15789/1563-0625-2013-4-369-374https://doaj.org/article/764cb34163d343b488bfa3108d381f162014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/648https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activity of the cells. Infectious syndrome in acute leukemia patients was accompanied by changes in antibody-dependent cytotoxicity against neutrophils (decreased CD16 and increase in CD64 expression), lower phagocytic capacity of the cells, and myeloperoxidase deficiency of neutrophils and monocytes. In patients with inflammatory manifestations of infectious syndrome (i.e., acute tonsillitis, bronchitis, pneumonia, etc.), the signs of neutrophilic insussiciency were more pronounced, i.e., CD16+ neutrophils comprised 24.36±7.43%, as compared with 74.21±5.43% in controls, p < 0.001; MPO positivity was detected in 29.15±12.6% of the cells against 96.1±1.94% in controls, p < 0.01; MPO expression: 5.34±3.07 MFI, with 32.9±10.76 in controls, p < 0,05. These data suggest significant disturbances of anti-infectious elimination mechanisms.S. V. PlotnikovaL. F. AznabaevaG. Sh. SafuanovaSPb RAACIarticleneutrophilsmonocytesdifferentiation clustersacute leukemiainfectious complicationsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 4, Pp 369-374 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophils monocytes differentiation clusters acute leukemia infectious complications Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophils monocytes differentiation clusters acute leukemia infectious complications Immunologic diseases. Allergy RC581-607 S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
description	Abstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activity of the cells. Infectious syndrome in acute leukemia patients was accompanied by changes in antibody-dependent cytotoxicity against neutrophils (decreased CD16 and increase in CD64 expression), lower phagocytic capacity of the cells, and myeloperoxidase deficiency of neutrophils and monocytes. In patients with inflammatory manifestations of infectious syndrome (i.e., acute tonsillitis, bronchitis, pneumonia, etc.), the signs of neutrophilic insussiciency were more pronounced, i.e., CD16+ neutrophils comprised 24.36±7.43%, as compared with 74.21±5.43% in controls, p < 0.001; MPO positivity was detected in 29.15±12.6% of the cells against 96.1±1.94% in controls, p < 0.01; MPO expression: 5.34±3.07 MFI, with 32.9±10.76 in controls, p < 0,05. These data suggest significant disturbances of anti-infectious elimination mechanisms.
format	article
author	S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova
author_facet	S. V. Plotnikova L. F. Aznabaeva G. Sh. Safuanova
author_sort	S. V. Plotnikova
title	CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
title_short	CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
title_full	CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
title_fullStr	CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
title_full_unstemmed	CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
title_sort	characteristics of phagocytic cells in patients with acute leukemia with an infectious syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/764cb34163d343b488bfa3108d381f16
work_keys_str_mv	AT svplotnikova characteristicsofphagocyticcellsinpatientswithacuteleukemiawithaninfectioussyndrome AT lfaznabaeva characteristicsofphagocyticcellsinpatientswithacuteleukemiawithaninfectioussyndrome AT gshsafuanova characteristicsofphagocyticcellsinpatientswithacuteleukemiawithaninfectioussyndrome
_version_	1718422427488223232

CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME

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