Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts

Photodynamic therapy (PDT) provides a potential therapeutic approach for killing malignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive p...

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Autores principales:	Lun-Zhang Guo, Cheng-Ham Wu, Ming-Fong Tsai, Fong-Yu Cheng, Vijayakumar Shanmugam, Zen-Uong Tsai, Zhiming Zhang, Tzu-Ming Liu, Chen-Sheng Yeh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Au nanorod nanopeanut two-photon fluorescence photodynamic therapy fluorescence resonance energy transfer Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/765463186fe24d93837c03a5dbfcd11c
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spelling	oai:doaj.org-article:765463186fe24d93837c03a5dbfcd11c2021-11-25T16:39:40ZPlasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts10.3390/app1122108752076-3417https://doaj.org/article/765463186fe24d93837c03a5dbfcd11c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10875https://doaj.org/toc/2076-3417Photodynamic therapy (PDT) provides a potential therapeutic approach for killing malignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive photodynamic platform, providing maximum tissue penetration. Here, we present a gold nanopeanut platform exhibiting dual functions of NIR PDT and two-photon luminescence imaging. The nanopeanut with a size less than 100 nm exhibits two distinct NIR surface plasmon absorption bands at approximately 1110 and 1300 nm. To perform PDT, we conjugated commercial toluidine blue O (TBO) PS on the surface of the nanopeanuts. With spectral overlap, the 1230-nm femtosecond Cr: forsterite laser can excite the surface plasmons of nanopeanuts, transfer energy to TBO, and generate singlet oxygen to kill cells. Moreover, the plasmon resonance-enhanced two-photon luminescence of nanopeanuts can be used to map their delivery in vivo. These results demonstrate that the PS-conjugated gold nanopeanut is an effective theranostic system for NIR PDT.Lun-Zhang GuoCheng-Ham WuMing-Fong TsaiFong-Yu ChengVijayakumar ShanmugamZen-Uong TsaiZhiming ZhangTzu-Ming LiuChen-Sheng YehMDPI AGarticleAu nanorodnanopeanuttwo-photon fluorescencephotodynamic therapyfluorescence resonance energy transferTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10875, p 10875 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Au nanorod nanopeanut two-photon fluorescence photodynamic therapy fluorescence resonance energy transfer Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	Au nanorod nanopeanut two-photon fluorescence photodynamic therapy fluorescence resonance energy transfer Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Lun-Zhang Guo Cheng-Ham Wu Ming-Fong Tsai Fong-Yu Cheng Vijayakumar Shanmugam Zen-Uong Tsai Zhiming Zhang Tzu-Ming Liu Chen-Sheng Yeh Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
description	Photodynamic therapy (PDT) provides a potential therapeutic approach for killing malignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive photodynamic platform, providing maximum tissue penetration. Here, we present a gold nanopeanut platform exhibiting dual functions of NIR PDT and two-photon luminescence imaging. The nanopeanut with a size less than 100 nm exhibits two distinct NIR surface plasmon absorption bands at approximately 1110 and 1300 nm. To perform PDT, we conjugated commercial toluidine blue O (TBO) PS on the surface of the nanopeanuts. With spectral overlap, the 1230-nm femtosecond Cr: forsterite laser can excite the surface plasmons of nanopeanuts, transfer energy to TBO, and generate singlet oxygen to kill cells. Moreover, the plasmon resonance-enhanced two-photon luminescence of nanopeanuts can be used to map their delivery in vivo. These results demonstrate that the PS-conjugated gold nanopeanut is an effective theranostic system for NIR PDT.
format	article
author	Lun-Zhang Guo Cheng-Ham Wu Ming-Fong Tsai Fong-Yu Cheng Vijayakumar Shanmugam Zen-Uong Tsai Zhiming Zhang Tzu-Ming Liu Chen-Sheng Yeh
author_facet	Lun-Zhang Guo Cheng-Ham Wu Ming-Fong Tsai Fong-Yu Cheng Vijayakumar Shanmugam Zen-Uong Tsai Zhiming Zhang Tzu-Ming Liu Chen-Sheng Yeh
author_sort	Lun-Zhang Guo
title	Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
title_short	Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
title_full	Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
title_fullStr	Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
title_full_unstemmed	Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts
title_sort	plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/765463186fe24d93837c03a5dbfcd11c
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Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts

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