The Fusion of <i>CLEC12A</i> and <i>MIR223HG</i> Arises from a <i>trans</i>-Splicing Event in Normal and Transformed Human Cells

The Fusion of <i>CLEC12A</i> and <i>MIR223HG</i> Arises from a <i>trans</i>-Splicing Event in Normal and Transformed Human Cells

Chimeric RNAs are often associated with chromosomal rearrangements in cancer. In addition, they are also widely detected in normal tissues, contributing to transcriptomic complexity. Despite their prevalence, little is known about the characteristics and functions of chimeric RNAs. Here, we examine...

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Autores principales: Bijay P. Dhungel, Geoffray Monteuuis, Caroline Giardina, Mehdi S. Tabar, Yue Feng, Cynthia Metierre, Sarah Ho, Rajini Nagarajah, Angela R. M. Fontaine, Jaynish S. Shah, Divya Gokal, Charles G. Bailey, Ulf Schmitz, John E. J. Rasko
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
chimeric RNAs
Fusion RNAs encoding protein
fusion transcript
linc-223
miR-223 host gene
trans-splicing
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/76580557ad97406c8cd6513f7e7d7f09
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https://doaj.org/article/76580557ad97406c8cd6513f7e7d7f09

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