Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep

Abstract Gastrointestinal nematode (GIN) infections have negative impacts on animal health, welfare and production. Information from molecular studies can highlight the underlying genetic mechanisms that enhance host resistance to GIN. However, such information often lacks for traditionally managed...

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Autores principales:	A. M. Ahbara, M. Rouatbi, M. Gharbi, M. Rekik, A. Haile, B. Rischkowsky, J. M. Mwacharo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7658c100259c473e88e8ea6f0b7343fb
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spelling	oai:doaj.org-article:7658c100259c473e88e8ea6f0b7343fb2021-12-02T13:41:22ZGenome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep10.1038/s41598-021-88501-32045-2322https://doaj.org/article/7658c100259c473e88e8ea6f0b7343fb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88501-3https://doaj.org/toc/2045-2322Abstract Gastrointestinal nematode (GIN) infections have negative impacts on animal health, welfare and production. Information from molecular studies can highlight the underlying genetic mechanisms that enhance host resistance to GIN. However, such information often lacks for traditionally managed indigenous livestock. Here, we analysed 600 K single nucleotide polymorphism genotypes of GIN infected and non-infected traditionally managed autochthonous Tunisian sheep grazing communal natural pastures. Population structure analysis did not find genetic differentiation that is consistent with infection status. However, by contrasting the infected versus non-infected cohorts using ROH, LR-GWAS, FST and XP-EHH, we identified 35 candidate regions that overlapped between at least two methods. Nineteen regions harboured QTLs for parasite resistance, immune capacity and disease susceptibility and, ten regions harboured QTLs for production (growth) and meat and carcass (fatness and anatomy) traits. The analysis also revealed candidate regions spanning genes enhancing innate immune defence (SLC22A4, SLC22A5, IL-4, IL-13), intestinal wound healing/repair (IL-4, VIL1, CXCR1, CXCR2) and GIN expulsion (IL-4, IL-13). Our results suggest that traditionally managed indigenous sheep have evolved multiple strategies that evoke and enhance GIN resistance and developmental stability. They confirm the importance of obtaining information from indigenous sheep to investigate genomic regions of functional significance in understanding the architecture of GIN resistance.A. M. AhbaraM. RouatbiM. GharbiM. RekikA. HaileB. RischkowskyJ. M. MwacharoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. M. Ahbara M. Rouatbi M. Gharbi M. Rekik A. Haile B. Rischkowsky J. M. Mwacharo Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
description	Abstract Gastrointestinal nematode (GIN) infections have negative impacts on animal health, welfare and production. Information from molecular studies can highlight the underlying genetic mechanisms that enhance host resistance to GIN. However, such information often lacks for traditionally managed indigenous livestock. Here, we analysed 600 K single nucleotide polymorphism genotypes of GIN infected and non-infected traditionally managed autochthonous Tunisian sheep grazing communal natural pastures. Population structure analysis did not find genetic differentiation that is consistent with infection status. However, by contrasting the infected versus non-infected cohorts using ROH, LR-GWAS, FST and XP-EHH, we identified 35 candidate regions that overlapped between at least two methods. Nineteen regions harboured QTLs for parasite resistance, immune capacity and disease susceptibility and, ten regions harboured QTLs for production (growth) and meat and carcass (fatness and anatomy) traits. The analysis also revealed candidate regions spanning genes enhancing innate immune defence (SLC22A4, SLC22A5, IL-4, IL-13), intestinal wound healing/repair (IL-4, VIL1, CXCR1, CXCR2) and GIN expulsion (IL-4, IL-13). Our results suggest that traditionally managed indigenous sheep have evolved multiple strategies that evoke and enhance GIN resistance and developmental stability. They confirm the importance of obtaining information from indigenous sheep to investigate genomic regions of functional significance in understanding the architecture of GIN resistance.
format	article
author	A. M. Ahbara M. Rouatbi M. Gharbi M. Rekik A. Haile B. Rischkowsky J. M. Mwacharo
author_facet	A. M. Ahbara M. Rouatbi M. Gharbi M. Rekik A. Haile B. Rischkowsky J. M. Mwacharo
author_sort	A. M. Ahbara
title	Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
title_short	Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
title_full	Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
title_fullStr	Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
title_full_unstemmed	Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep
title_sort	genome-wide insights on gastrointestinal nematode resistance in autochthonous tunisian sheep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7658c100259c473e88e8ea6f0b7343fb
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Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep

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