Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease

Shihui Fu, Yuan Liu, Bing Zhu, Tiehui Xiao, Shuangyan Yi, Yongyi Bai, Ping Ye, Leiming LuoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of ChinaObjective: As a standard indicator of renal function, the glomerular filtration rate (GFR) is vital f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fu S, Liu Y, Zhu B, Xiao T, Yi S, Bai Y, Ye P, Luo L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Chronic kidney disease coronary artery disease glomerular filtration rate equation elderly. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/765a6206ac384b3f85480f189f8ae160
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:765a6206ac384b3f85480f189f8ae160
record_format	dspace
spelling	oai:doaj.org-article:765a6206ac384b3f85480f189f8ae1602021-12-02T06:58:42ZPrognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease1178-1998https://doaj.org/article/765a6206ac384b3f85480f189f8ae1602013-02-01T00:00:00Zhttps://www.dovepress.com/prognostic-abilities-of-different-calculation-formulas-for-the-glomeru-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Shihui Fu, Yuan Liu, Bing Zhu, Tiehui Xiao, Shuangyan Yi, Yongyi Bai, Ping Ye, Leiming LuoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of ChinaObjective: As a standard indicator of renal function, the glomerular filtration rate (GFR) is vital for the prognostic analysis of elderly patients with coronary artery disease (CAD). Thus, the search for the calculation equation of GFR with the best prognostic ability is an important task. The most commonly used Modification of Diet in Renal Disease (MDRD) equation and the Chinese version (CMDRD) of the MDRD equation has many shortcomings. The newly developed Mayo Clinic quadratic (Mayo) and Chronic Kidney Disease (CKD) Epidemiology Collaboration (CKD-EPI) equations may overcome these shortcomings. Because the populations involved in these equation-related studies are almost completely devoid of subjects > 70 years of age, there are more debates on the performance of these equations in the elderly. This study was designed to compare the prognostic abilities of different calculation formulas for the GFR in elderly Chinese patients with CAD.Methods: This study included 1050 patients (≥60 years of age) with CAD. The endpoint was all-cause mortality over a mean follow-up period of 417 days.Results: The median age was 86 years (60–104 years). The median values for the MDRD-GFR, CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 66.0, 69.2, 65.6, and 75.8 mL/minute/1.73 m2, respectively. The prevalence of GFR < 60 mL/minute/1.73 m2 based on these measures was 39.3%, 35.4%, 43.0%, and 28.7%, respectively. Their area under the curve values for predicting death were 0.611, 0.610, 0.625, and 0.632, respectively. Their cut-off points for predicting death were 54.1, 53.5, 48.0, and 57.4 mL/minute/1.73 m2, respectively. Compared with the MDRD-GFR, the net reclassification improvement values of the CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 0.02, 0.10, and 0.14, respectively.Conclusion: The prognostic abilities of the CKD-EPI and Mayo equations were significantly superior to the MDRD and CMDRD equations; the Mayo equation had a mild, but not statistically significant superiority compared with the CKD-EPI equation in elderly Chinese patients with CAD.Keywords: chronic kidney disease, coronary artery disease, glomerular filtration rate, equation, elderlyFu SLiu YZhu BXiao TYi SBai YYe PLuo LDove Medical PressarticleChronic kidney diseasecoronary artery diseaseglomerular filtration rateequationelderly.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 229-237 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic kidney disease coronary artery disease glomerular filtration rate equation elderly. Geriatrics RC952-954.6
spellingShingle	Chronic kidney disease coronary artery disease glomerular filtration rate equation elderly. Geriatrics RC952-954.6 Fu S Liu Y Zhu B Xiao T Yi S Bai Y Ye P Luo L Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
description	Shihui Fu, Yuan Liu, Bing Zhu, Tiehui Xiao, Shuangyan Yi, Yongyi Bai, Ping Ye, Leiming LuoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of ChinaObjective: As a standard indicator of renal function, the glomerular filtration rate (GFR) is vital for the prognostic analysis of elderly patients with coronary artery disease (CAD). Thus, the search for the calculation equation of GFR with the best prognostic ability is an important task. The most commonly used Modification of Diet in Renal Disease (MDRD) equation and the Chinese version (CMDRD) of the MDRD equation has many shortcomings. The newly developed Mayo Clinic quadratic (Mayo) and Chronic Kidney Disease (CKD) Epidemiology Collaboration (CKD-EPI) equations may overcome these shortcomings. Because the populations involved in these equation-related studies are almost completely devoid of subjects > 70 years of age, there are more debates on the performance of these equations in the elderly. This study was designed to compare the prognostic abilities of different calculation formulas for the GFR in elderly Chinese patients with CAD.Methods: This study included 1050 patients (≥60 years of age) with CAD. The endpoint was all-cause mortality over a mean follow-up period of 417 days.Results: The median age was 86 years (60–104 years). The median values for the MDRD-GFR, CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 66.0, 69.2, 65.6, and 75.8 mL/minute/1.73 m2, respectively. The prevalence of GFR < 60 mL/minute/1.73 m2 based on these measures was 39.3%, 35.4%, 43.0%, and 28.7%, respectively. Their area under the curve values for predicting death were 0.611, 0.610, 0.625, and 0.632, respectively. Their cut-off points for predicting death were 54.1, 53.5, 48.0, and 57.4 mL/minute/1.73 m2, respectively. Compared with the MDRD-GFR, the net reclassification improvement values of the CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 0.02, 0.10, and 0.14, respectively.Conclusion: The prognostic abilities of the CKD-EPI and Mayo equations were significantly superior to the MDRD and CMDRD equations; the Mayo equation had a mild, but not statistically significant superiority compared with the CKD-EPI equation in elderly Chinese patients with CAD.Keywords: chronic kidney disease, coronary artery disease, glomerular filtration rate, equation, elderly
format	article
author	Fu S Liu Y Zhu B Xiao T Yi S Bai Y Ye P Luo L
author_facet	Fu S Liu Y Zhu B Xiao T Yi S Bai Y Ye P Luo L
author_sort	Fu S
title	Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
title_short	Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
title_full	Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
title_fullStr	Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
title_full_unstemmed	Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease
title_sort	prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly chinese patients with coronary artery disease
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/765a6206ac384b3f85480f189f8ae160
work_keys_str_mv	AT fus prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT liuy prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT zhub prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT xiaot prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT yis prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT baiy prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT yep prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease AT luol prognosticabilitiesofdifferentcalculationformulasfortheglomerularfiltrationrateinelderlychinesepatientswithcoronaryarterydisease
_version_	1718399640562302976

Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease

Ejemplares similares