Simulation of left atrial function using a multi-scale model of the cardiovascular system.

During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to characterize the left atrium, first, because this theory has known limitations, and second, because it is s...

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Autores principales:	Antoine Pironet, Pierre C Dauby, Sabine Paeme, Sarah Kosta, J Geoffrey Chase, Thomas Desaive
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/765c748bcea24f2587c1d09665a97e9c
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spelling	oai:doaj.org-article:765c748bcea24f2587c1d09665a97e9c2021-11-18T07:43:14ZSimulation of left atrial function using a multi-scale model of the cardiovascular system.1932-620310.1371/journal.pone.0065146https://doaj.org/article/765c748bcea24f2587c1d09665a97e9c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23755183/?tool=EBIhttps://doaj.org/toc/1932-6203During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to characterize the left atrium, first, because this theory has known limitations, and second, because it is still uncertain whether the load independence hypothesis holds. In this study, we aim to bypass this uncertainty by relying on another kind of mathematical model of the cardiac chambers. In the present work, we describe both the left atrium and the left ventricle with a multi-scale model. The multi-scale property of this model comes from the fact that pressure inside a cardiac chamber is derived from a model of the sarcomere behavior. Macroscopic model parameters are identified from reference dog hemodynamic data. The multi-scale model of the cardiovascular system including the left atrium is then simulated to show that the physiological roles of the left atrium are correctly reproduced. This include a biphasic pressure wave and an eight-shaped pressure-volume loop. We also test the validity of our model in non basal conditions by reproducing a preload reduction experiment by inferior vena cava occlusion with the model. We compute the variation of eight indices before and after this experiment and obtain the same variation as experimentally observed for seven out of the eight indices. In summary, the multi-scale mathematical model presented in this work is able to correctly account for the three roles of the left atrium and also exhibits a realistic left atrial pressure-volume loop. Furthermore, the model has been previously presented and validated for the left ventricle. This makes it a proper alternative to the time-varying elastance theory if the focus is set on precisely representing the left atrial and left ventricular behaviors.Antoine PironetPierre C DaubySabine PaemeSarah KostaJ Geoffrey ChaseThomas DesaivePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65146 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antoine Pironet Pierre C Dauby Sabine Paeme Sarah Kosta J Geoffrey Chase Thomas Desaive Simulation of left atrial function using a multi-scale model of the cardiovascular system.
description	During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to characterize the left atrium, first, because this theory has known limitations, and second, because it is still uncertain whether the load independence hypothesis holds. In this study, we aim to bypass this uncertainty by relying on another kind of mathematical model of the cardiac chambers. In the present work, we describe both the left atrium and the left ventricle with a multi-scale model. The multi-scale property of this model comes from the fact that pressure inside a cardiac chamber is derived from a model of the sarcomere behavior. Macroscopic model parameters are identified from reference dog hemodynamic data. The multi-scale model of the cardiovascular system including the left atrium is then simulated to show that the physiological roles of the left atrium are correctly reproduced. This include a biphasic pressure wave and an eight-shaped pressure-volume loop. We also test the validity of our model in non basal conditions by reproducing a preload reduction experiment by inferior vena cava occlusion with the model. We compute the variation of eight indices before and after this experiment and obtain the same variation as experimentally observed for seven out of the eight indices. In summary, the multi-scale mathematical model presented in this work is able to correctly account for the three roles of the left atrium and also exhibits a realistic left atrial pressure-volume loop. Furthermore, the model has been previously presented and validated for the left ventricle. This makes it a proper alternative to the time-varying elastance theory if the focus is set on precisely representing the left atrial and left ventricular behaviors.
format	article
author	Antoine Pironet Pierre C Dauby Sabine Paeme Sarah Kosta J Geoffrey Chase Thomas Desaive
author_facet	Antoine Pironet Pierre C Dauby Sabine Paeme Sarah Kosta J Geoffrey Chase Thomas Desaive
author_sort	Antoine Pironet
title	Simulation of left atrial function using a multi-scale model of the cardiovascular system.
title_short	Simulation of left atrial function using a multi-scale model of the cardiovascular system.
title_full	Simulation of left atrial function using a multi-scale model of the cardiovascular system.
title_fullStr	Simulation of left atrial function using a multi-scale model of the cardiovascular system.
title_full_unstemmed	Simulation of left atrial function using a multi-scale model of the cardiovascular system.
title_sort	simulation of left atrial function using a multi-scale model of the cardiovascular system.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/765c748bcea24f2587c1d09665a97e9c
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Simulation of left atrial function using a multi-scale model of the cardiovascular system.

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