Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells...
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Nature Portfolio
2021
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oai:doaj.org-article:765d12e51ea74ac084ead2b6c27e16992021-12-02T18:51:36ZRing finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity10.1038/s41467-021-26061-w2041-1723https://doaj.org/article/765d12e51ea74ac084ead2b6c27e16992021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26061-whttps://doaj.org/toc/2041-1723During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells.Fabien TheryLia MartinaCaroline AsselmanYifeng ZhangMadeleine VesselyHeidi RepoKoen SedeynGeorge D. MoschonasClara BredowQi Wen TeoJingshu ZhangKevin LeandroDenzel EggermontDelphine De SutterKatie BoucherTino HochepiedNele FestjensNico CallewaertXavier SaelensBart DermautKlaus-Peter KnobelochAntje BelingSumana SanyalLilliana RadoshevichSven EyckermanFrancis ImpensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Fabien Thery Lia Martina Caroline Asselman Yifeng Zhang Madeleine Vessely Heidi Repo Koen Sedeyn George D. Moschonas Clara Bredow Qi Wen Teo Jingshu Zhang Kevin Leandro Denzel Eggermont Delphine De Sutter Katie Boucher Tino Hochepied Nele Festjens Nico Callewaert Xavier Saelens Bart Dermaut Klaus-Peter Knobeloch Antje Beling Sumana Sanyal Lilliana Radoshevich Sven Eyckerman Francis Impens Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| description |
During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells. |
| format |
article |
| author |
Fabien Thery Lia Martina Caroline Asselman Yifeng Zhang Madeleine Vessely Heidi Repo Koen Sedeyn George D. Moschonas Clara Bredow Qi Wen Teo Jingshu Zhang Kevin Leandro Denzel Eggermont Delphine De Sutter Katie Boucher Tino Hochepied Nele Festjens Nico Callewaert Xavier Saelens Bart Dermaut Klaus-Peter Knobeloch Antje Beling Sumana Sanyal Lilliana Radoshevich Sven Eyckerman Francis Impens |
| author_facet |
Fabien Thery Lia Martina Caroline Asselman Yifeng Zhang Madeleine Vessely Heidi Repo Koen Sedeyn George D. Moschonas Clara Bredow Qi Wen Teo Jingshu Zhang Kevin Leandro Denzel Eggermont Delphine De Sutter Katie Boucher Tino Hochepied Nele Festjens Nico Callewaert Xavier Saelens Bart Dermaut Klaus-Peter Knobeloch Antje Beling Sumana Sanyal Lilliana Radoshevich Sven Eyckerman Francis Impens |
| author_sort |
Fabien Thery |
| title |
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| title_short |
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| title_full |
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| title_fullStr |
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| title_full_unstemmed |
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity |
| title_sort |
ring finger protein 213 assembles into a sensor for isgylated proteins with antimicrobial activity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/765d12e51ea74ac084ead2b6c27e1699 |
| work_keys_str_mv |
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| _version_ |
1718377391943843840 |