Assessing tuberculosis case fatality ratio: a meta-analysis.

<h4>Background</h4>Recently, the tuberculosis (TB) Task Force Impact Measurement acknowledged the need to review the assumptions underlying the TB mortality estimates published annually by the World Health Organization (WHO). TB mortality is indirectly measured by multiplying estimated T...

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Autores principales:	Masja Straetemans, Philippe Glaziou, Ana L Bierrenbach, Charalambos Sismanidis, Marieke J van der Werf
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/765d794952734319a0f2dea3d0850e0a
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spelling	oai:doaj.org-article:765d794952734319a0f2dea3d0850e0a2021-11-18T06:51:16ZAssessing tuberculosis case fatality ratio: a meta-analysis.1932-620310.1371/journal.pone.0020755https://doaj.org/article/765d794952734319a0f2dea3d0850e0a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738585/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recently, the tuberculosis (TB) Task Force Impact Measurement acknowledged the need to review the assumptions underlying the TB mortality estimates published annually by the World Health Organization (WHO). TB mortality is indirectly measured by multiplying estimated TB incidence with estimated case fatality ratio (CFR). We conducted a meta-analysis to estimate the TB case fatality ratio in TB patients having initiated TB treatment.<h4>Methods</h4>We searched for eligible studies in the PubMed and Embase databases through March 4(th) 2011 and by reference listing of relevant review articles. Main analyses included the estimation of the pooled percentages of: a) TB patients dying due to TB after having initiated TB treatment and b) TB patients dying during TB treatment. Pooled percentages were estimated using random effects regression models on the combined patient population from all studies.<h4>Main results</h4>We identified 69 relevant studies of which 22 provided data on mortality due to TB and 59 provided data on mortality during TB treatment. Among HIV infected persons the pooled percentage of TB patients dying due to TB was 9.2% (95% Confidence Interval (CI): 3.7%-14.7%) and among HIV uninfected persons 3.0% (95% CI: -1.2%-7.4%) based on the results of eight and three studies respectively providing data for this analyses. The pooled percentage of TB patients dying during TB treatment was 18.8% (95% CI: 14.8%-22.8%) among HIV infected patients and 3.5% (95% CI: 2.0%-4.92%) among HIV uninfected patients based on the results of 27 and 19 studies respectively.<h4>Conclusion</h4>The results of the literature review are useful in generating prior distributions of CFR in countries with vital registration systems and have contributed towards revised estimates of TB mortality This literature review did not provide us with all data needed for a valid estimation of TB CFR in TB patients initiating TB treatment.Masja StraetemansPhilippe GlaziouAna L BierrenbachCharalambos SismanidisMarieke J van der WerfPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20755 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masja Straetemans Philippe Glaziou Ana L Bierrenbach Charalambos Sismanidis Marieke J van der Werf Assessing tuberculosis case fatality ratio: a meta-analysis.
description	<h4>Background</h4>Recently, the tuberculosis (TB) Task Force Impact Measurement acknowledged the need to review the assumptions underlying the TB mortality estimates published annually by the World Health Organization (WHO). TB mortality is indirectly measured by multiplying estimated TB incidence with estimated case fatality ratio (CFR). We conducted a meta-analysis to estimate the TB case fatality ratio in TB patients having initiated TB treatment.<h4>Methods</h4>We searched for eligible studies in the PubMed and Embase databases through March 4(th) 2011 and by reference listing of relevant review articles. Main analyses included the estimation of the pooled percentages of: a) TB patients dying due to TB after having initiated TB treatment and b) TB patients dying during TB treatment. Pooled percentages were estimated using random effects regression models on the combined patient population from all studies.<h4>Main results</h4>We identified 69 relevant studies of which 22 provided data on mortality due to TB and 59 provided data on mortality during TB treatment. Among HIV infected persons the pooled percentage of TB patients dying due to TB was 9.2% (95% Confidence Interval (CI): 3.7%-14.7%) and among HIV uninfected persons 3.0% (95% CI: -1.2%-7.4%) based on the results of eight and three studies respectively providing data for this analyses. The pooled percentage of TB patients dying during TB treatment was 18.8% (95% CI: 14.8%-22.8%) among HIV infected patients and 3.5% (95% CI: 2.0%-4.92%) among HIV uninfected patients based on the results of 27 and 19 studies respectively.<h4>Conclusion</h4>The results of the literature review are useful in generating prior distributions of CFR in countries with vital registration systems and have contributed towards revised estimates of TB mortality This literature review did not provide us with all data needed for a valid estimation of TB CFR in TB patients initiating TB treatment.
format	article
author	Masja Straetemans Philippe Glaziou Ana L Bierrenbach Charalambos Sismanidis Marieke J van der Werf
author_facet	Masja Straetemans Philippe Glaziou Ana L Bierrenbach Charalambos Sismanidis Marieke J van der Werf
author_sort	Masja Straetemans
title	Assessing tuberculosis case fatality ratio: a meta-analysis.
title_short	Assessing tuberculosis case fatality ratio: a meta-analysis.
title_full	Assessing tuberculosis case fatality ratio: a meta-analysis.
title_fullStr	Assessing tuberculosis case fatality ratio: a meta-analysis.
title_full_unstemmed	Assessing tuberculosis case fatality ratio: a meta-analysis.
title_sort	assessing tuberculosis case fatality ratio: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/765d794952734319a0f2dea3d0850e0a
work_keys_str_mv	AT masjastraetemans assessingtuberculosiscasefatalityratioametaanalysis AT philippeglaziou assessingtuberculosiscasefatalityratioametaanalysis AT analbierrenbach assessingtuberculosiscasefatalityratioametaanalysis AT charalambossismanidis assessingtuberculosiscasefatalityratioametaanalysis AT mariekejvanderwerf assessingtuberculosiscasefatalityratioametaanalysis
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Assessing tuberculosis case fatality ratio: a meta-analysis.

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