The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark in AD, is recognized as the main cau...

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Autores principales:	Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pathological tau Synaptic dysfunction Synaptic plasticity Alzheimer’s disease Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/765eab5126d74de6b3567f70393b2d75
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spelling	oai:doaj.org-article:765eab5126d74de6b3567f70393b2d752021-11-14T12:31:41ZThe role of pathological tau in synaptic dysfunction in Alzheimer’s diseases10.1186/s40035-021-00270-12047-9158https://doaj.org/article/765eab5126d74de6b3567f70393b2d752021-11-01T00:00:00Zhttps://doi.org/10.1186/s40035-021-00270-1https://doaj.org/toc/2047-9158Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark in AD, is recognized as the main cause of the cognitive impairments. Accumulating evidence suggests that synaptic dysfunction could be an early pathological event in AD. Pathological tau, which is detached from axonal microtubules and mislocalized into pre- and postsynaptic neuronal compartments, is suggested to induce synaptic dysfunction in several ways, including reducing mobility and release of presynaptic vesicles, decreasing glutamatergic receptors, impairing the maturation of dendritic spines at postsynaptic terminals, disrupting mitochondrial transport and function in synapses, and promoting the phagocytosis of synapses by microglia. Here, we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in AD. We propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD.Moxin WuManqing ZhangXiaoping YinKai ChenZhijian HuQin ZhouXianming CaoZhiying ChenDan LiuBMCarticlePathological tauSynaptic dysfunctionSynaptic plasticityAlzheimer’s diseaseNeurology. Diseases of the nervous systemRC346-429ENTranslational Neurodegeneration, Vol 10, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathological tau Synaptic dysfunction Synaptic plasticity Alzheimer’s disease Neurology. Diseases of the nervous system RC346-429
spellingShingle	Pathological tau Synaptic dysfunction Synaptic plasticity Alzheimer’s disease Neurology. Diseases of the nervous system RC346-429 Moxin Wu Manqing Zhang Xiaoping Yin Kai Chen Zhijian Hu Qin Zhou Xianming Cao Zhiying Chen Dan Liu The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
description	Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark in AD, is recognized as the main cause of the cognitive impairments. Accumulating evidence suggests that synaptic dysfunction could be an early pathological event in AD. Pathological tau, which is detached from axonal microtubules and mislocalized into pre- and postsynaptic neuronal compartments, is suggested to induce synaptic dysfunction in several ways, including reducing mobility and release of presynaptic vesicles, decreasing glutamatergic receptors, impairing the maturation of dendritic spines at postsynaptic terminals, disrupting mitochondrial transport and function in synapses, and promoting the phagocytosis of synapses by microglia. Here, we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in AD. We propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD.
format	article
author	Moxin Wu Manqing Zhang Xiaoping Yin Kai Chen Zhijian Hu Qin Zhou Xianming Cao Zhiying Chen Dan Liu
author_facet	Moxin Wu Manqing Zhang Xiaoping Yin Kai Chen Zhijian Hu Qin Zhou Xianming Cao Zhiying Chen Dan Liu
author_sort	Moxin Wu
title	The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
title_short	The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
title_full	The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
title_fullStr	The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
title_full_unstemmed	The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
title_sort	role of pathological tau in synaptic dysfunction in alzheimer’s diseases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/765eab5126d74de6b3567f70393b2d75
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The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

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