Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study
Abstract Background Streptococcus pneumoniae (S. pneumoniae) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community. Here, we focused on penicillin/cefotaxime...
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2021
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oai:doaj.org-article:765fedb11010498ebd239e93d19a26d22021-11-21T12:42:43ZAntibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study10.1186/s12879-021-06860-81471-2334https://doaj.org/article/765fedb11010498ebd239e93d19a26d22021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06860-8https://doaj.org/toc/1471-2334Abstract Background Streptococcus pneumoniae (S. pneumoniae) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community. Here, we focused on penicillin/cefotaxime non-susceptibility of S. pneumoniae and evaluated appropriateness of targeted antibiotic therapy for children with IPD (invasive pneumococcal diseases) in China. Methods A multicenter retrospective study was conducted in 14 hospitals from 13 provinces in China. Antibiotics prescription, clinical features and resistance patterns of IPD cases from January 2012 to December 2017 were collected. Appropriateness of targeted antibiotics therapy was assessed. Results 806 IPD cases were collected. The non-susceptibility rates of S. pneumoniae to penicillin and cefotaxime were 40.9% and 20.7% respectively in 492 non-meningitis cases, whereas those were 73.2% and 43.0% respectively in 314 meningitis cases. Carbapenems were used in 21.3% of non-meningitis cases and 42.0% of meningitis cases for targeted therapy. For 390 non-meningitis cases with isolates susceptible to cefotaxime, vancomycin and linezolid were used in 17.9% and 8.7% of cases respectively for targeted therapy. For 179 meningitis cases with isolates susceptible to cefotaxime, vancomycin and linezolid were prescribed in 55.3% and 15.6% of cases respectively. Overall, inappropriate targeted therapies were identified in 361 (44.8%) of 806 IPD cases, including 232 (28.8%) cases with inappropriate use of carbapenems, 169 (21.0%) cases with inappropriate use of vancomycin and 62 (7.7%) cases with inappropriate use of linezolid. Conclusions Antibiotic regimens for IPD definite therapy were often excessive with extensive prescription of carbapenems, vancomycin or linezolid in China. Antimicrobial stewardship programs should be implemented to improve antimicrobial use.Tian-ming ChenWen-hui LiFang WangKun TanQing-xiong ZhuKai ZhouShi-hua LiuJing LiuJing BiHui-ling DengXue-xia ChenJuan LiYu-min WangQing ZhaoLiang ZhuHui-xuan MaZhi LiJi-kui DengChun-hui ZhuKang-kang WuAi-wei LinShuang-jie LiDong-meng WangHui-jun CaiShi-yong ZhaoXu-dong LuLan YeFang DongWen-shuang ZhangYong-hong YangGang LiuBMCarticleInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Infectious and parasitic diseases RC109-216 |
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Infectious and parasitic diseases RC109-216 Tian-ming Chen Wen-hui Li Fang Wang Kun Tan Qing-xiong Zhu Kai Zhou Shi-hua Liu Jing Liu Jing Bi Hui-ling Deng Xue-xia Chen Juan Li Yu-min Wang Qing Zhao Liang Zhu Hui-xuan Ma Zhi Li Ji-kui Deng Chun-hui Zhu Kang-kang Wu Ai-wei Lin Shuang-jie Li Dong-meng Wang Hui-jun Cai Shi-yong Zhao Xu-dong Lu Lan Ye Fang Dong Wen-shuang Zhang Yong-hong Yang Gang Liu Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| description |
Abstract Background Streptococcus pneumoniae (S. pneumoniae) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community. Here, we focused on penicillin/cefotaxime non-susceptibility of S. pneumoniae and evaluated appropriateness of targeted antibiotic therapy for children with IPD (invasive pneumococcal diseases) in China. Methods A multicenter retrospective study was conducted in 14 hospitals from 13 provinces in China. Antibiotics prescription, clinical features and resistance patterns of IPD cases from January 2012 to December 2017 were collected. Appropriateness of targeted antibiotics therapy was assessed. Results 806 IPD cases were collected. The non-susceptibility rates of S. pneumoniae to penicillin and cefotaxime were 40.9% and 20.7% respectively in 492 non-meningitis cases, whereas those were 73.2% and 43.0% respectively in 314 meningitis cases. Carbapenems were used in 21.3% of non-meningitis cases and 42.0% of meningitis cases for targeted therapy. For 390 non-meningitis cases with isolates susceptible to cefotaxime, vancomycin and linezolid were used in 17.9% and 8.7% of cases respectively for targeted therapy. For 179 meningitis cases with isolates susceptible to cefotaxime, vancomycin and linezolid were prescribed in 55.3% and 15.6% of cases respectively. Overall, inappropriate targeted therapies were identified in 361 (44.8%) of 806 IPD cases, including 232 (28.8%) cases with inappropriate use of carbapenems, 169 (21.0%) cases with inappropriate use of vancomycin and 62 (7.7%) cases with inappropriate use of linezolid. Conclusions Antibiotic regimens for IPD definite therapy were often excessive with extensive prescription of carbapenems, vancomycin or linezolid in China. Antimicrobial stewardship programs should be implemented to improve antimicrobial use. |
| format |
article |
| author |
Tian-ming Chen Wen-hui Li Fang Wang Kun Tan Qing-xiong Zhu Kai Zhou Shi-hua Liu Jing Liu Jing Bi Hui-ling Deng Xue-xia Chen Juan Li Yu-min Wang Qing Zhao Liang Zhu Hui-xuan Ma Zhi Li Ji-kui Deng Chun-hui Zhu Kang-kang Wu Ai-wei Lin Shuang-jie Li Dong-meng Wang Hui-jun Cai Shi-yong Zhao Xu-dong Lu Lan Ye Fang Dong Wen-shuang Zhang Yong-hong Yang Gang Liu |
| author_facet |
Tian-ming Chen Wen-hui Li Fang Wang Kun Tan Qing-xiong Zhu Kai Zhou Shi-hua Liu Jing Liu Jing Bi Hui-ling Deng Xue-xia Chen Juan Li Yu-min Wang Qing Zhao Liang Zhu Hui-xuan Ma Zhi Li Ji-kui Deng Chun-hui Zhu Kang-kang Wu Ai-wei Lin Shuang-jie Li Dong-meng Wang Hui-jun Cai Shi-yong Zhao Xu-dong Lu Lan Ye Fang Dong Wen-shuang Zhang Yong-hong Yang Gang Liu |
| author_sort |
Tian-ming Chen |
| title |
Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| title_short |
Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| title_full |
Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| title_fullStr |
Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| title_full_unstemmed |
Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study |
| title_sort |
antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in china: a multicenter retrospective study |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/765fedb11010498ebd239e93d19a26d2 |
| work_keys_str_mv |
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