Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients

Wenjing Shi, Qi Zhao, Xue Zhao, Chuan Xing, Bing He Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Bing He Email hb3h@hotmail.comPurpose: To compare the endocrine and metabolic indexes of obese and normal body mass ind...

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Autores principales:	Shi W, Zhao Q, Zhao X, Xing C, He B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	polycystic ovary syndrome insulin resistance obesity hyperandrogenemia endocrine metabolism Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/76605326ba9a4a04b3eb6627c9439f8c
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spelling	oai:doaj.org-article:76605326ba9a4a04b3eb6627c9439f8c2021-12-02T19:19:53ZAnalysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients1178-7007https://doaj.org/article/76605326ba9a4a04b3eb6627c9439f8c2021-10-01T00:00:00Zhttps://www.dovepress.com/analysis-of-endocrine-and-metabolic-indexes-in-non-obese-patients-with-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Wenjing Shi, Qi Zhao, Xue Zhao, Chuan Xing, Bing He Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Bing He Email hb3h@hotmail.comPurpose: To compare the endocrine and metabolic indexes of obese and normal body mass index (BMI) polycystic ovary syndrome (PCOS) patients, and explore factors affecting the pathogenesis and progression of PCOS.Methods: This study included obese (n=79) and normal BMI (n=40) PCOS patients, and obese (n=30) and normal BMI (n=30) non-PCOS controls. Blood glucose, insulin (INS), blood lipids, sex hormones, and other metabolic and endocrine indicators were measured, and the correlations between the indicators were analyzed.Results: HOMA-IR, 0min INS, 60min INS, 120min INS, 180min INS, FAI, TG, TC, LDL-C and sd-LDL in obese PCOS group were higher, while SHBG, LH, LH/FSH and HDL-C were lower than those in normal weight PCOS group (P < 0.05). 120min PBG, HOMA-IR, FAI, T, LH, LH/FSH, AMH, TC and LDL-C in obese PCOS group were higher than those in obese control group (P < 0.05). 0min PBG, 60min PBG, 120min PBG, 180min PBG, 0min INS, 60min INS, 120min INS, 180min INS, HOMA-IR, LH, LH/FSH and T in normal weight PCOS group were higher than those in normal weight control group (P < 0.05). In both normal weight group and obesity group, HOMA-IR entered the regression equation with FAI as dependent variable, and the absolute value of HOMA-IR standardized partial regression coefficient was higher than that of hs-CRP and AMH. In PCOS patients, FAI in the obese and non-obese PCOS groups was positively correlated with HOMA-IR.Conclusion: Endocrine metabolic disorders in women with PCOS were more obvious than that in women with non-PCOS with matched BMI. The abnormality of glucose and lipid metabolism in obese PCOS patients is more serious than that in PCOS patients with normal BMI. Both obese and normal BMI PCOS patients were affected by hyperinsulinemia, and IR may play a key role in the pathogenesis and development of PCOS.Keywords: polycystic ovary syndrome, insulin resistance, obesity, hyperandrogenemia, endocrine metabolismShi WZhao QZhao XXing CHe BDove Medical Pressarticlepolycystic ovary syndromeinsulin resistanceobesityhyperandrogenemiaendocrine metabolismSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4275-4281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polycystic ovary syndrome insulin resistance obesity hyperandrogenemia endocrine metabolism Specialties of internal medicine RC581-951
spellingShingle	polycystic ovary syndrome insulin resistance obesity hyperandrogenemia endocrine metabolism Specialties of internal medicine RC581-951 Shi W Zhao Q Zhao X Xing C He B Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
description	Wenjing Shi, Qi Zhao, Xue Zhao, Chuan Xing, Bing He Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Bing He Email hb3h@hotmail.comPurpose: To compare the endocrine and metabolic indexes of obese and normal body mass index (BMI) polycystic ovary syndrome (PCOS) patients, and explore factors affecting the pathogenesis and progression of PCOS.Methods: This study included obese (n=79) and normal BMI (n=40) PCOS patients, and obese (n=30) and normal BMI (n=30) non-PCOS controls. Blood glucose, insulin (INS), blood lipids, sex hormones, and other metabolic and endocrine indicators were measured, and the correlations between the indicators were analyzed.Results: HOMA-IR, 0min INS, 60min INS, 120min INS, 180min INS, FAI, TG, TC, LDL-C and sd-LDL in obese PCOS group were higher, while SHBG, LH, LH/FSH and HDL-C were lower than those in normal weight PCOS group (P < 0.05). 120min PBG, HOMA-IR, FAI, T, LH, LH/FSH, AMH, TC and LDL-C in obese PCOS group were higher than those in obese control group (P < 0.05). 0min PBG, 60min PBG, 120min PBG, 180min PBG, 0min INS, 60min INS, 120min INS, 180min INS, HOMA-IR, LH, LH/FSH and T in normal weight PCOS group were higher than those in normal weight control group (P < 0.05). In both normal weight group and obesity group, HOMA-IR entered the regression equation with FAI as dependent variable, and the absolute value of HOMA-IR standardized partial regression coefficient was higher than that of hs-CRP and AMH. In PCOS patients, FAI in the obese and non-obese PCOS groups was positively correlated with HOMA-IR.Conclusion: Endocrine metabolic disorders in women with PCOS were more obvious than that in women with non-PCOS with matched BMI. The abnormality of glucose and lipid metabolism in obese PCOS patients is more serious than that in PCOS patients with normal BMI. Both obese and normal BMI PCOS patients were affected by hyperinsulinemia, and IR may play a key role in the pathogenesis and development of PCOS.Keywords: polycystic ovary syndrome, insulin resistance, obesity, hyperandrogenemia, endocrine metabolism
format	article
author	Shi W Zhao Q Zhao X Xing C He B
author_facet	Shi W Zhao Q Zhao X Xing C He B
author_sort	Shi W
title	Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
title_short	Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
title_full	Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
title_fullStr	Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
title_full_unstemmed	Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients
title_sort	analysis of endocrine and metabolic indexes in non-obese patients with polycystic ovary syndrome and its compare with obese patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/76605326ba9a4a04b3eb6627c9439f8c
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Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients

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