Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study

Tetsuya Muto, Shigeki Machida Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Purpose: To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein...

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Autores principales:	Muto T, Machida S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	corneal endothelium macular edema retinal vein occlusion vascular endothelial growth factor Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7662c9af21484c38a2c0992e8285dcc1
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spelling	oai:doaj.org-article:7662c9af21484c38a2c0992e8285dcc12021-12-02T04:25:47ZEffect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study1177-5483https://doaj.org/article/7662c9af21484c38a2c0992e8285dcc12019-02-01T00:00:00Zhttps://www.dovepress.com/effect-of-intravitreal-aflibercept-on-corneal-endothelial-cells-a-6-mo-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tetsuya Muto, Shigeki Machida Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Purpose: To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein occlusion. Material and methods: Forty-six eyes of 44 consecutive patients (27 men, 17 women; age range: 55–88 years) were evaluated. All participants initially received a single intravitreal injection of aflibercept (2 mg in 0.05 mL), followed by pro re nata use and underwent central corneal specular microscopy before the injection and at 1, 3 and 6 months after the first injection during a 6-month follow-up period. The endothelial cell density (ECD), average cell size (AVG), standard deviation of cell size (SD), coefficient of variation of cell size (CoV), maximum of cell size (MAX), minimum of cell size (MIN) and percentage of hexagonal cells (Hex%) were analyzed and the central corneal thickness (CCT) was measured. Results: No significant differences in the ECD, AVG, SD, CoV, MIN, Hex% and CCT were observed between measurements obtained before and 1, 3 and 6 months after the first injection. However, the MAX measured before injection differed significantly from the values measured at 1, 3 and 6 months after the first injection (P=0.033). An average of 1.43±0.58 intravitreal aflibercept injections were administered per patient. Conclusion: These study findings indicate that the intravitreal administration of aflibercept (2 mg) might very slightly alter the corneal endothelium within 6 months of the first injection. Keywords: corneal endothelium, macular edema, retinal vein occlusion, vascular endothelial growth factorMuto TMachida SDove Medical Pressarticlecorneal endotheliummacular edemaretinal vein occlusionvascular endothelial growth factorOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 373-381 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal endothelium macular edema retinal vein occlusion vascular endothelial growth factor Ophthalmology RE1-994
spellingShingle	corneal endothelium macular edema retinal vein occlusion vascular endothelial growth factor Ophthalmology RE1-994 Muto T Machida S Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
description	Tetsuya Muto, Shigeki Machida Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Purpose: To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein occlusion. Material and methods: Forty-six eyes of 44 consecutive patients (27 men, 17 women; age range: 55–88 years) were evaluated. All participants initially received a single intravitreal injection of aflibercept (2 mg in 0.05 mL), followed by pro re nata use and underwent central corneal specular microscopy before the injection and at 1, 3 and 6 months after the first injection during a 6-month follow-up period. The endothelial cell density (ECD), average cell size (AVG), standard deviation of cell size (SD), coefficient of variation of cell size (CoV), maximum of cell size (MAX), minimum of cell size (MIN) and percentage of hexagonal cells (Hex%) were analyzed and the central corneal thickness (CCT) was measured. Results: No significant differences in the ECD, AVG, SD, CoV, MIN, Hex% and CCT were observed between measurements obtained before and 1, 3 and 6 months after the first injection. However, the MAX measured before injection differed significantly from the values measured at 1, 3 and 6 months after the first injection (P=0.033). An average of 1.43±0.58 intravitreal aflibercept injections were administered per patient. Conclusion: These study findings indicate that the intravitreal administration of aflibercept (2 mg) might very slightly alter the corneal endothelium within 6 months of the first injection. Keywords: corneal endothelium, macular edema, retinal vein occlusion, vascular endothelial growth factor
format	article
author	Muto T Machida S
author_facet	Muto T Machida S
author_sort	Muto T
title	Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
title_short	Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
title_full	Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
title_fullStr	Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
title_full_unstemmed	Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
title_sort	effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7662c9af21484c38a2c0992e8285dcc1
work_keys_str_mv	AT mutot effectofintravitrealafliberceptoncornealendothelialcellsa6monthfollowupstudy AT machidas effectofintravitrealafliberceptoncornealendothelialcellsa6monthfollowupstudy
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Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study

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