Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis

The present study investigated the dietary and urinary OTA occurrence among 44 Lebanese children. Relying on HPLC-FLD analysis, OTA was found in all the urine samples and in 46.5% and 25% of the 24 h duplicate diet and dinner samples, respectively. The means of OTA levels in positive samples were 0....

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Autores principales:	Manar Al Ayoubi, Mohammad Salman, Lucia Gambacorta, Nada El Darra, Michele Solfrizzo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Ochratoxin A biomarker risk assessment urine duplicate diets exposure Medicine R
Acceso en línea:	https://doaj.org/article/766b9f13628f48229b5a1bd28596f424
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spelling	oai:doaj.org-article:766b9f13628f48229b5a1bd28596f4242021-11-25T19:08:53ZAssessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis10.3390/toxins131107952072-6651https://doaj.org/article/766b9f13628f48229b5a1bd28596f4242021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/795https://doaj.org/toc/2072-6651The present study investigated the dietary and urinary OTA occurrence among 44 Lebanese children. Relying on HPLC-FLD analysis, OTA was found in all the urine samples and in 46.5% and 25% of the 24 h duplicate diet and dinner samples, respectively. The means of OTA levels in positive samples were 0.32 ± 0.1 ng/g in 24 h diet, 0.32 ± 0.18 ng/g in dinner and 0.022 ± 0.012 ng/mL in urines. These values corresponded to margin of exposure (MOE) means of 7907 ± 5922 (neoplastic) and 2579 ± 1932 (non-neoplastic) calculated from positive 24 h diet, while 961 ± 599 (neoplastic) and 313 ± 195 (non-neoplastic) calculated from the urine. Since the MOE levels for the neoplastic effect were below the limit (10,000), a major health threat was detected and must be addressed as a health institutions’ priority. Besides, the wide difference between PDIs and MOEs calculated from food and urine suggests conducting further OTA’s toxicokinetics studies before using urine to measure OTA exposure.Manar Al AyoubiMohammad SalmanLucia GambacortaNada El DarraMichele SolfrizzoMDPI AGarticleOchratoxin Abiomarkerrisk assessmenturineduplicate dietsexposureMedicineRENToxins, Vol 13, Iss 795, p 795 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ochratoxin A biomarker risk assessment urine duplicate diets exposure Medicine R
spellingShingle	Ochratoxin A biomarker risk assessment urine duplicate diets exposure Medicine R Manar Al Ayoubi Mohammad Salman Lucia Gambacorta Nada El Darra Michele Solfrizzo Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
description	The present study investigated the dietary and urinary OTA occurrence among 44 Lebanese children. Relying on HPLC-FLD analysis, OTA was found in all the urine samples and in 46.5% and 25% of the 24 h duplicate diet and dinner samples, respectively. The means of OTA levels in positive samples were 0.32 ± 0.1 ng/g in 24 h diet, 0.32 ± 0.18 ng/g in dinner and 0.022 ± 0.012 ng/mL in urines. These values corresponded to margin of exposure (MOE) means of 7907 ± 5922 (neoplastic) and 2579 ± 1932 (non-neoplastic) calculated from positive 24 h diet, while 961 ± 599 (neoplastic) and 313 ± 195 (non-neoplastic) calculated from the urine. Since the MOE levels for the neoplastic effect were below the limit (10,000), a major health threat was detected and must be addressed as a health institutions’ priority. Besides, the wide difference between PDIs and MOEs calculated from food and urine suggests conducting further OTA’s toxicokinetics studies before using urine to measure OTA exposure.
format	article
author	Manar Al Ayoubi Mohammad Salman Lucia Gambacorta Nada El Darra Michele Solfrizzo
author_facet	Manar Al Ayoubi Mohammad Salman Lucia Gambacorta Nada El Darra Michele Solfrizzo
author_sort	Manar Al Ayoubi
title	Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
title_short	Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
title_full	Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
title_fullStr	Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
title_full_unstemmed	Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis
title_sort	assessment of dietary exposure to ochratoxin a in lebanese students and its urinary biomarker analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/766b9f13628f48229b5a1bd28596f424
work_keys_str_mv	AT manaralayoubi assessmentofdietaryexposuretoochratoxinainlebanesestudentsanditsurinarybiomarkeranalysis AT mohammadsalman assessmentofdietaryexposuretoochratoxinainlebanesestudentsanditsurinarybiomarkeranalysis AT luciagambacorta assessmentofdietaryexposuretoochratoxinainlebanesestudentsanditsurinarybiomarkeranalysis AT nadaeldarra assessmentofdietaryexposuretoochratoxinainlebanesestudentsanditsurinarybiomarkeranalysis AT michelesolfrizzo assessmentofdietaryexposuretoochratoxinainlebanesestudentsanditsurinarybiomarkeranalysis
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Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis

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